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Review
. 2024 Jul 25;40(7):2022-2037.
doi: 10.13345/j.cjb.240021.

[Mutation of the envelope stress-responsive protein CpxA capable of regulating the antimicrobial resistance and virulence of bacteria]

[Article in Chinese]
Xueqin Xie  1   2   3 , Xinyao Li  4 , Jingyan Huang  1 , Suneng Xu  1 , Yiling Chen  1 , Yuhang Qiu  4 , Minchen Tang  4 , Huilin Xie  5 , Qiqi Deng  4 , Jinghan Huang  5
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Free article
Review

[Mutation of the envelope stress-responsive protein CpxA capable of regulating the antimicrobial resistance and virulence of bacteria]

[Article in Chinese]
Xueqin Xie et al. Sheng Wu Gong Cheng Xue Bao. .
Free article

Abstract

CpxA is a key member of the envelope stress-responsive Cpx two-component system ubiquitous in Gram-negative bacteria. It is responsible for signal sensing and has dual activities of phosphatase and kinase. CpxA has been revealed to participate in the regulation of physiological processes such as virulence and antimicrobial resistance of bacteria. In recent years, the development of novel antimicrobials targeting CpxA has attracted much attention. Drugs developed based on inhibition of the phosphatase activity of CpxA have shown effectiveness in the treatment of urinary tract infections caused by Escherichia coli. This review introduces the structure and functional domains of CpxA and the activation of Cpx pathways by CpxA. Furthermore, it summarizes the roles of CpxA in the development of antimicrobial resistance and the regulation of bacterial virulence and reviews the latest progress in the development of new antimicrobials targeting this protein. It is expected to assist in the exploration of CpxA-targeting anti-infection strategies for severely antimicrobial-resistant bacteria whose clinical infections are of urgent need to be controlled.

Keywords: CpxA; antimicrobial susceptibility; envelope stress-responsive system; mutation; pathogenicity; targets of antimicrobial therapies.

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