SARS-CoV-2 Seropositivity in Urban Population of Wild Fallow Deer, Dublin, Ireland, 2020-2022
- PMID: 39043403
- PMCID: PMC11286063
- DOI: 10.3201/eid3008.231056
SARS-CoV-2 Seropositivity in Urban Population of Wild Fallow Deer, Dublin, Ireland, 2020-2022
Abstract
SARS-CoV-2 can infect wildlife, and SARS-CoV-2 variants of concern might expand into novel animal reservoirs, potentially by reverse zoonosis. White-tailed deer and mule deer of North America are the only deer species in which SARS-CoV-2 has been documented, raising the question of whether other reservoir species exist. We report cases of SARS-CoV-2 seropositivity in a fallow deer population located in Dublin, Ireland. Sampled deer were seronegative in 2020 when the Alpha variant was circulating in humans, 1 deer was seropositive for the Delta variant in 2021, and 12/21 (57%) sampled deer were seropositive for the Omicron variant in 2022, suggesting host tropism expansion as new variants emerged in humans. Omicron BA.1 was capable of infecting fallow deer lung type-2 pneumocytes and type-1-like pneumocytes or endothelial cells ex vivo. Ongoing surveillance to identify novel SARS-CoV-2 reservoirs is needed to prevent public health risks during human-animal interactions in periurban settings.
Keywords: COVID-19; Dublin; Ireland; SARS; SARS-CoV-2; cervid; coronavirus; coronavirus disease; deer; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; wildlife reservoir; zoonoses.
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References
-
- World Health Organization. WHO COVID-19 dashboard [cited 2023 Jul 21]. https://covid19.who.int
-
- European Centre for Disease Prevention and Control. SARS-CoV-2 in animals: susceptibility of animal species, risk for animal and public health, monitoring, prevention and control. February 28, 2023. [cited 2023 Jul 21]. https://www.ecdc.europa.eu/en/publications-data/sars-cov-2-animals-susce... - PMC - PubMed
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