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Review
. 2024 Sep;26(9):953-971.
doi: 10.1007/s11886-024-02099-2. Epub 2024 Jul 23.

Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer

Amit Manhas  1   2 , Dipti Tripathi  1   3   2 , Dilip Thomas  1 , Nazish Sayed  4   5   6
Affiliations
Review

Cardiovascular Toxicity in Cancer Therapy: Protecting the Heart while Combating Cancer

Amit Manhas et al. Curr Cardiol Rep. 2024 Sep.

Abstract

Purpose of review: This review explores the cardiovascular toxicity associated with cancer therapies, emphasizing the significance of the growing field of cardio-oncology. It aims to elucidate the mechanisms of cardiotoxicity due to radiotherapy, chemotherapy, and targeted therapies, and to discuss the advancements in human induced pluripotent stem cell technology (hiPSC) for predictive disease modeling.

Recent findings: Recent studies have identified several chemotherapeutic agents, including anthracyclines and kinase inhibitors, that significantly increase cardiovascular risks. Advances in hiPSC technology have enabled the differentiation of these cells into cardiovascular lineages, facilitating more accurate modeling of drug-induced cardiotoxicity. Moreover, integrating hiPSCs into clinical trials holds promise for personalized cardiotoxicity assessments, potentially enhancing patient-specific therapeutic strategies. Cardio-oncology bridges oncology and cardiology to mitigate the cardiovascular side-effects of cancer treatments. Despite advancements in predictive models using hiPSCs, challenges persist in accurately replicating adult heart tissue and ensuring reproducibility. Ongoing research is essential for developing personalized therapies that balance effective cancer treatment with minimal cardiovascular harm.

Keywords: 3D models; Cardiotoxicity; Chemotherapy; Pharmacogenomics; iPSCs.

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