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. 2024 Jul 16;5(7):101651.
doi: 10.1016/j.xcrm.2024.101651.

All (remains) in the family? Using healthy relatives to define Crohn's gut microbiome alterations

Amnon Amir  1 , Yael Haberman  2
Affiliations

All (remains) in the family? Using healthy relatives to define Crohn's gut microbiome alterations

Amnon Amir et al. Cell Rep Med. .

Abstract

Gut microbial imbalance is noted in Crohn's disease (CD), but the specific bacteria associated with CD vary between studies. Chen et al.1 pair CD patients with their healthy first-degree relatives to mitigate some of the environmental and genetic effects.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
Using healthy relatives to define Crohn’s gut microbiome alterations While family members share similar genetics, environmental exposures, and diet, not all relatives will eventually develop CD. Focusing on the microbial differences between CD cases and healthy controls from the same family may enable the detection of disease-development-associated bacteria without confounding household-related factors.
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