Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

doi:10.1007/s12032-024-02443-0

Review

. 2024 Jul 13;41(8):201.

doi: 10.1007/s12032-024-02443-0.

Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

Affiliations

¹ Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
² Department of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
³ Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
⁴ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, 303012, Rajasthan, India.
⁵ Department of Applied Sciences, Chandigarh Engineering Colleges, Chandigarh Group of Colleges, Jhanjeri, 140307, Mohali, Punjab, India.
⁶ Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
⁷ Department of Medical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
⁸ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁹ College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
¹⁰ Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq.
¹¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. irfancsmmu@gmail.com.
¹² College of Pharmacy, The Islamic University, Najaf, Iraq.
¹³ College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹⁴ College of Pharmacy, The Islamic University of Babylon, Babylon, Iraq.

PMID: 39001987
DOI: 10.1007/s12032-024-02443-0

Review

Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

Mohamed J Saadh et al. Med Oncol. 2024.

. 2024 Jul 13;41(8):201.

doi: 10.1007/s12032-024-02443-0.

Authors

Affiliations

¹ Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan.
² Department of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
³ Department of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
⁴ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, 303012, Rajasthan, India.
⁵ Department of Applied Sciences, Chandigarh Engineering Colleges, Chandigarh Group of Colleges, Jhanjeri, 140307, Mohali, Punjab, India.
⁶ Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
⁷ Department of Medical Engineering, Al-Hadi University College, Baghdad, 10011, Iraq.
⁸ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁹ College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
¹⁰ Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq.
¹¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. irfancsmmu@gmail.com.
¹² College of Pharmacy, The Islamic University, Najaf, Iraq.
¹³ College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹⁴ College of Pharmacy, The Islamic University of Babylon, Babylon, Iraq.

PMID: 39001987
DOI: 10.1007/s12032-024-02443-0

Abstract

Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different cells and proteins, plays a crucial role in tumor growth and chemoresistance. Targeting tumor stroma, consisting of diverse non-tumor cells such as fibroblasts, extracellular matrix (ECM), immune cells, and also pre-vascular cells is encouraging for remodeling solid cancers, such as pancreatic cancer. Remodeling the stroma of pancreas tumors can be suggested as a strategy for reducing resistance to chemo/immunotherapy. Several studies have shown that phytochemicals from plants can affect the tumor environment and have anti-cancer properties. By targeting key pathways involved in stromal activation, phytochemicals may disrupt communication between the tumor and stroma and make tumor cells more sensitive to different treatments. Additionally, phytochemicals have immunomodulatory and anti-angiogenic properties, all of which contribute to their potential in treating pancreatic cancer. This review will provide a detailed look at how phytochemicals impact the tumor stroma and their effects on pancreatic tumor growth, spread, and response to treatment. It will also explore the potential of combining phytochemicals with other treatment options like chemotherapy, immunotherapy, and radiation.

Keywords: Cancer-Associated Fibroblasts; Nanoparticles; Pancreatic Tumor; Phytochemicals; Tumor stroma.

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References

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1. Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, et al. SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation. Cancer Lett. 2024;587:216733. https://doi.org/10.1016/j.canlet.2024.216733 . - DOI - PubMed
1. Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, et al. Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. Drug Resist Updat. 2023;71:101005. https://doi.org/10.1016/j.drup.2023.101005 . - DOI - PubMed
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[1] Gaianigo N, Melisi D, Carbone C. EMT and treatment resistance in pancreatic cancer. Cancers (Basel). 2017;9(9):122. - PubMed - DOI

[2] Gaianigo N, Melisi D, Carbone C. EMT and treatment resistance in pancreatic cancer. Cancers (Basel). 2017;9(9):122. - PubMed - DOI

[3] Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, et al. SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation. Cancer Lett. 2024;587:216733. https://doi.org/10.1016/j.canlet.2024.216733 . - DOI - PubMed

[4] Yuan J, Zhu Z, Zhang P, Ashrafizadeh M, Abd El-Aty AM, Hacımüftüoğlu A, et al. SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation. Cancer Lett. 2024;587:216733. https://doi.org/10.1016/j.canlet.2024.216733 . - DOI - PubMed

[5] Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, et al. Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. Drug Resist Updat. 2023;71:101005. https://doi.org/10.1016/j.drup.2023.101005 . - DOI - PubMed

[6] Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, et al. Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer. Drug Resist Updat. 2023;71:101005. https://doi.org/10.1016/j.drup.2023.101005 . - DOI - PubMed

[7] Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J Oncol. 2019;10(1):10. - PubMed - PMC - DOI

[8] Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World J Oncol. 2019;10(1):10. - PubMed - PMC - DOI

[9] Kikuyama M, Kamisawa T, Kuruma S, Chiba K, Kawaguchi S, Terada S, Satoh T. Early diagnosis to improve the poor prognosis of pancreatic cancer. Cancers (Basel). 2018;10(2):48. - PubMed - DOI

[10] Kikuyama M, Kamisawa T, Kuruma S, Chiba K, Kawaguchi S, Terada S, Satoh T. Early diagnosis to improve the poor prognosis of pancreatic cancer. Cancers (Basel). 2018;10(2):48. - PubMed - DOI

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Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

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Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations

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