Targeting ROS in cancer: rationale and strategies

doi:10.1038/s41573-024-00979-4

Review

. 2024 Aug;23(8):583-606.

doi: 10.1038/s41573-024-00979-4. Epub 2024 Jul 9.

Targeting ROS in cancer: rationale and strategies

Christophe Glorieux¹, Shihua Liu¹, Dunyaporn Trachootham², Peng Huang^{3

4}

Affiliations

¹ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
² Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
³ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. huangpeng@sysucc.org.cn.
⁴ Metabolic Innovation Center, Sun Yat-Sen University, Guangzhou, China. huangpeng@sysucc.org.cn.

PMID: 38982305
DOI: 10.1038/s41573-024-00979-4

Review

Targeting ROS in cancer: rationale and strategies

Christophe Glorieux et al. Nat Rev Drug Discov. 2024 Aug.

. 2024 Aug;23(8):583-606.

doi: 10.1038/s41573-024-00979-4. Epub 2024 Jul 9.

Authors

Christophe Glorieux¹, Shihua Liu¹, Dunyaporn Trachootham², Peng Huang^{3

4}

Affiliations

¹ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
² Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand.
³ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. huangpeng@sysucc.org.cn.
⁴ Metabolic Innovation Center, Sun Yat-Sen University, Guangzhou, China. huangpeng@sysucc.org.cn.

PMID: 38982305
DOI: 10.1038/s41573-024-00979-4

Abstract

Reactive oxygen species (ROS) in biological systems are transient but essential molecules that are generated and eliminated by a complex set of delicately balanced molecular machineries. Disruption of redox homeostasis has been associated with various human diseases, especially cancer, in which increased ROS levels are thought to have a major role in tumour development and progression. As such, modulation of cellular redox status by targeting ROS and their regulatory machineries is considered a promising therapeutic strategy for cancer treatment. Recently, there has been major progress in this field, including the discovery of novel redox signalling pathways that affect the metabolism of tumour cells as well as immune cells in the tumour microenvironment, and the intriguing ROS regulation of biomolecular phase separation. Progress has also been made in exploring redox regulation in cancer stem cells, the role of ROS in determining cell fate and new anticancer agents that target ROS. This Review discusses these research developments and their implications for cancer therapy and drug discovery, as well as emerging concepts, paradoxes and future perspectives.

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References

1. Halliwell, B. Reactive oxygen species (ROS), oxygen radicals and antioxidants: where are we now, where is the field going and where should we go? Biochem. Biophys. Res. Commun. 633, 17–19 (2022). - PubMed
1. Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell Biol. 23, 499–515 (2022). - PubMed
1. Trachootham, D., Lu, W., Ogasawara, M. A., Nilsa, R. D. & Huang, P. Redox regulation of cell survival. Antioxid. Redox Signal. 10, 1343–1374 (2008). - PubMed - PMC
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1. Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discov. 8, 579–591 (2009). - PubMed

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[1] Halliwell, B. Reactive oxygen species (ROS), oxygen radicals and antioxidants: where are we now, where is the field going and where should we go? Biochem. Biophys. Res. Commun. 633, 17–19 (2022). - PubMed

[2] Halliwell, B. Reactive oxygen species (ROS), oxygen radicals and antioxidants: where are we now, where is the field going and where should we go? Biochem. Biophys. Res. Commun. 633, 17–19 (2022). - PubMed

[3] Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell Biol. 23, 499–515 (2022). - PubMed

[4] Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell Biol. 23, 499–515 (2022). - PubMed

[5] Trachootham, D., Lu, W., Ogasawara, M. A., Nilsa, R. D. & Huang, P. Redox regulation of cell survival. Antioxid. Redox Signal. 10, 1343–1374 (2008). - PubMed - PMC

[6] Trachootham, D., Lu, W., Ogasawara, M. A., Nilsa, R. D. & Huang, P. Redox regulation of cell survival. Antioxid. Redox Signal. 10, 1343–1374 (2008). - PubMed - PMC

[7] Gorrini, C., Harris, I. S. & Mak, T. W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 12, 931–947 (2013). - PubMed

[8] Gorrini, C., Harris, I. S. & Mak, T. W. Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 12, 931–947 (2013). - PubMed

[9] Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discov. 8, 579–591 (2009). - PubMed

[10] Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat. Rev. Drug Discov. 8, 579–591 (2009). - PubMed

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Targeting ROS in cancer: rationale and strategies

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Targeting ROS in cancer: rationale and strategies

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