Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 9;299(1):67.
doi: 10.1007/s00438-024-02160-3.

Population dynamics and genetic isolation in the Central Himalayan region: insights from Sikkim population, India

Gaurav Priyank  1 , Avinash Vahinde  1 , Penny H Niranjan  1 , Vivek Sahajpal  2 , Deepika Bhandari  3 , Ajay S Rana  2 , Satish Kumar  4 , Malay Shukla  4 , Sweta Nidhi  1 , Abhishek Singh  5
Affiliations

Population dynamics and genetic isolation in the Central Himalayan region: insights from Sikkim population, India

Gaurav Priyank et al. Mol Genet Genomics. .

Abstract

India's rich diversity encompasses individuals from varied geographical, cultural, and ethnic backgrounds. In the field of population genetics, comprehending the genetic diversity across distinct populations plays a crucial role. This study presents significant findings from genetic data obtained from the Sikkimese population of India. Autosomal markers were crucial for evaluating forensic parameters, with a combined paternity index of 1 × 109. Notably, Penta E emerged as a distinguishing marker for individual identification in the Sikkim population. Fst genetic distance values revealed insights into genetic isolation among different groups, enhancing our understanding of population dynamics in the central Himalayan region. The NJ-based phylogenetic tree highlighted close genetic relationships, of the Sikkim population with the Nepalese population surrounding neighbouring Himalayan populations providing glimpses into common ancestry. In summary, this study contributes valuable data to population genetics and underscores the importance of genetic variation in comprehending population dynamics and forensic applications.

Keywords: Genetic diversity; Genetic isolation; Population structure; Sikkim.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Balamurugan K, Kanthimathi S, Vijaya M, Suhasini G, Duncan G, Tracey M, Budowle B (2010) Genetic variation of 15 autosomal microsatellite loci in a tamil population from Tamil Nadu, Southern India. Legal Med (Tokyo Japan) 12(6):320–323. https://doi.org/10.1016/j.legalmed.2010.07.004 - DOI
    1. Basnet R, Rai N, Tamang R, Awasthi NP, Pradhan I, Parajuli P, Kashyap D, Reddy AG, Chaubey G, Das Manandhar K, Shrestha TR, Thangaraj K (2023) The matrilineal ancestry of Nepali populations. Hum Genet 142(2):167–180. https://doi.org/10.1007/s00439-022-02488-z - DOI - PubMed
    1. Bland JM, Altman DG (1995) Multiple significance tests: the Bonferroni method. Brit Med J. 310;170.
    1. Evanno G, Regnaut S, Goudet J (2005) Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. Mol Ecol 14(8):2611–2620. https://doi.org/10.1111/j.1365-294X.2005.02553.x - DOI - PubMed
    1. Gayden T, Mirabal S, Cadenas AM, Lacau H, Simms TM, Morlote D, Chennakrishnaiah S, Herrera RJ (2009) Genetic insights into the origins of Tibeto-Burman populations in the Himalayas. J Hum Genet 54(4):216–223. https://doi.org/10.1038/jhg.2009.14 - DOI - PubMed

Supplementary concepts

LinkOut - more resources