Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jul;42(4):428-437.
doi: 10.1007/s00774-024-01527-1. Epub 2024 Jul 8.

Mechanisms of osteoporosis associated with chronic obstructive pulmonary disease

Daisuke Inoue  1 , Reiko Inoue  2
Affiliations
Review

Mechanisms of osteoporosis associated with chronic obstructive pulmonary disease

Daisuke Inoue et al. J Bone Miner Metab. 2024 Jul.

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic respiratory symptoms due to inflammatory and destructive changes of the lung leading to progressive airflow obstruction. Fragility fractures associated with osteoporosis are among major comorbidities and have significant impacts on quality of life and prognosis of patients with COPD. Evidence suggests that both decreased bone mineral density (BMD) and impaired bone quality contribute to bone fragility and resultant fractures in COPD. Although various clinical risk factors of osteoporosis have been described, mechanisms of COPD-associated osteoporosis are still largely unknown. In addition, its specific treatment has not been established, either. Previous studies have suggested involvement of low BMI and sarcopenia in the pathogenesis of COPD-associated osteoporosis. In this narrative review, we will propose critical roles of vitamin D deficiency and inflammation, both of which are often present in COPD and may underlie the development of osteosarcopenia and impaired bone quality, ultimately causing fractures in COPD patients.

Keywords: Bone mineral density; Fracture; Inflammation; Trabecular bone score; Vitamin D.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Celli B, Fabbri L, Criner G, Martinez FJ, Mannino D, Vogelmeier C, Montes de Oca M, Papi A, Sin DD, Han MK, Agusti A (2022) Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision. Am J Respir Crit Care Med 206:1317–1325 - PubMed - PMC - DOI
    1. Brat K, Svoboda M, Zatloukal J, Plutinsky M, Volakova E, Popelkova P, Novotna B, Dvorak T, Koblizek V (2023) Prognostic properties of the GOLD 2023 classification system. Int J Chronic Obstr Pulmon Dis 18:661–667 - DOI
    1. Skajaa N, Laugesen K, Horváth-Puhó E, Sørensen HT (2023) Comorbidities and mortality among patients with chronic obstructive pulmonary disease. BMJ Open Respir Res. https://doi.org/10.1136/bmjresp-2023-001798 - DOI - PubMed - PMC
    1. Decramer M, Janssens W, Miravitlles M (2012) Chronic obstructive pulmonary disease. Lancet 379:1341–1351 - PubMed - PMC - DOI
    1. Frei A, Muggensturm P, Putcha N, Siebeling L, Zoller M, Boyd CM, ter Riet G, Puhan MA (2014) Five comorbidities reflected the health status in patients with chronic obstructive pulmonary disease: the newly developed COMCOLD index. J Clin Epidemiol 67:904–911 - PubMed - DOI

MeSH terms

LinkOut - more resources