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Review
. 2024 Nov;397(11):8633-8649.
doi: 10.1007/s00210-024-03243-z. Epub 2024 Jun 28.

Phytoactive drugs used in the treatment of Alzheimer's disease and dementia

Anshita Gupta Soni  1 , Astha Verma  2 , Renjil Joshi  3 , Kamal Shah  4 , Deependra Soni  5 , Chanchal Deep Kaur  1 , Swarnlata Saraf  6 , Nagendra Singh Chauhan  7
Affiliations
Review

Phytoactive drugs used in the treatment of Alzheimer's disease and dementia

Anshita Gupta Soni et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Nov.

Abstract

The prevalence of Alzheimer's disease and other forms of dementia is increasing worldwide, and finding effective treatments for these conditions is a major public health challenge. Natural bioactive drugs have been identified as a promising source of potential treatments, due to their ability to target multiple pathways and their low toxicity. This paper reviews the current state of research on natural bioactive drugs used in the treatment of Alzheimer's disease and other dementias. The paper summarizes the findings of studies on various natural compounds, including curcumin, resveratrol, caffeine, genistein, quercetin, GinkoBiloba, Withaniasomnifera, Ginseng Brahmi, Giloy, and huperzine, and their effects on cognitive function, neuroinflammation, and amyloid-beta accumulation. In this review, we discuss the mechanism of action involved in the treatment of Alzheimer's disease. The paper also discusses the challenges associated with developing natural bioactive drugs for dementia treatment, including issues related to bioavailability and standardization. Finally, the paper suggests directions for future research in this area, including the need for more rigorous clinical trials and the development of novel delivery systems to improve the efficacy of natural bioactive drugs. Overall, this review highlights the potential of natural bioactive drugs as a promising avenue for the development of safe and effective treatments for Alzheimer's disease and other dementias.

Keywords: Alzheimer; Bioactive; Dementias; Herbal drug.

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