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Review
. 2024 Jun 27;15(1):187.
doi: 10.1186/s13287-024-03781-6.

Effects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders

Zi-Xian Liu #  1   2   3 , Guan-Qiao Liu #  1   2 , Ze-Xin Lin #  1   2 , Ying-Qi Chen  1   2 , Peng Chen  1   2 , Yan-Jun Hu  1   2 , Bin Yu  4   5 , Nan Jiang  6   7
Affiliations
Review

Effects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders

Zi-Xian Liu et al. Stem Cell Res Ther. .

Abstract

Due to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have not been covered clearly. Meanwhile, with the intensive research on the mechanisms of stem cells in regulating various diseases, stem cell therapy is increasingly being attention because of its effectiveness and safety. As one of the most widely used stem cell in stem cell therapies, hematopoietic stem cell transplantation shows huge advantage in treatment of leukemia and other blood-malignant diseases. Besides, due to the effect of anti-inflammatory and immunomodulatory, mesenchymal stem cells could be a potential therapeutic strategy for variety infectious diseases. In this review, we summarized the effects of Staphylococcus aureus (S. aureus) and its components on different types of adult stem cells and their downstream signaling pathways. Also, we reviewed the roles of different kinds of stem cells in various disease models caused by S. aureus, providing new insights for applying stem cell therapy to treat infectious diseases.

Keywords: Adipose stem cells; Inflammatory disorders; Mesenchymal stem cells; Staphylococcus aureus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
The mechanism of how S. aureus interacts with stem cells
Fig. 2
Fig. 2
The role of stem cells in alleviating infectious and inflammatory disease
See this image and copyright information in PMC

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References

    1. Cheung GYC, Bae JS, Otto M. Pathogenicity and virulence of Staphylococcus aureus. Virulence. 2021;12(1):547–69. doi: 10.1080/21505594.2021.1878688. - DOI - PMC - PubMed
    1. Tong SYC, et al. Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management. Clin Microbiol Rev. 2015;28(3):603–61. doi: 10.1128/CMR.00134-14. - DOI - PMC - PubMed
    1. Cheung GYC, Bae JS, Otto M. Pathogenicity Virulence Virulence. 2021;12(1):547–69. - PMC - PubMed
    1. Ahmad-Mansour N et al. Toxins: an update on their pathogenic properties and potential treatments. Toxins, 2021. 13(10). - PMC - PubMed
    1. Marrazzo P, et al. Exploring the roles of MSCs in infections: focus on bacterial diseases. J Mol Med. 2019;97(4):437–50. doi: 10.1007/s00109-019-01752-6. - DOI - PubMed