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Review
. 2024 Aug:77:102467.
doi: 10.1016/j.coph.2024.102467. Epub 2024 Jun 18.

Pharmacological regulation of HIF-1α, RGC death, and glaucoma

Shahid Husain  1 , Ryan Leveckis  2
Affiliations
Review

Pharmacological regulation of HIF-1α, RGC death, and glaucoma

Shahid Husain et al. Curr Opin Pharmacol. 2024 Aug.

Abstract

Hypoxia can regulate oxygen-sensitive pathways that could be neuroprotective to compensate for the detrimental effects of low oxygen. However, prolonged hypoxia can activate neurodegenerative pathways. HIF-1α is upregulated/stabilized in hypoxic conditions, promoting alteration of gene expression, and ultimately leading to cell-death. Therefore, regulation of HIF-1α expression pharmacologically is a vital approach to mitigate cell death. In this review, we provide information showing the role of HIF-1α and its associated pathways in ocular retinopathies. We also discuss the beneficial roles of HIF-1α inhibitor, KC7F2, in ocular pathologies. Finally, we provided our own data demonstrating RGC neuroprotection by KC7F2 in glaucomatous animals.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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