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Review
. 2024 Oct;1871(7):119787.
doi: 10.1016/j.bbamcr.2024.119787. Epub 2024 Jun 13.

WhiB-like proteins: Diversity of structure, function and mechanism

Daisy Guiza Beltran  1 , Tao Wan  1 , LiMei Zhang  2
Affiliations
Review

WhiB-like proteins: Diversity of structure, function and mechanism

Daisy Guiza Beltran et al. Biochim Biophys Acta Mol Cell Res. 2024 Oct.

Abstract

The WhiB-Like (Wbl) proteins are a large family of iron-sulfur (Fe-S) cluster-containing transcription factors exclusively found in the phylum Actinobacteria, including the notable genera like Mycobacteria, Streptomycetes and Corynebacteria. These proteins play pivotal roles in diverse biological processes, such as cell development, redox stress response and antibiotic resistance. Members of the Wbl family exhibit remarkable diversity in their sequences, structures and functions, attracting great attention since their first discovery. This review highlights the most recent breakthroughs in understanding the structural and mechanistic aspects of Wbl-dependent transcriptional regulation.

Keywords: Actinobacteria; Iron-sulfur (Fe-S) cluster; Primary σ(70)-family sigma factor A (σ(A)); Transcription factor; WhiB-Like (Wbl).

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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