Clinical applications of monoclonal antibodies
- PMID: 3886376
- DOI: 10.1007/BF02148651
Clinical applications of monoclonal antibodies
Abstract
This review highlights the properties, problems, and potentials of monoclonal antibodies as diagnostic and therapeutic agents. The most extensive experience has been obtained with antibodies specific for functionally distinct subsets of lymphocytes. They have been used to monitor the immunosuppression of organ-graft recipients and to attempt to elucidate the disturbance of immunologic function in a variety of conditions. Current therapeutic applications under trial include immunosuppression to treat organ-graft rejection and to eliminate cells responsible for graft-vs-host disease from the bone marrow. Applications to cancer diagnosis and treatment have been hampered by the difficulty of identifying truly tumor-specific antigens. Successes have, however, been obtained in the location of metastases and in the extracorporeal treatment of autologous marrow to purge it of malignant cells, and, more rarely, with the direct administration of monoclonal antibodies in vivo. The conjugation of cell-type specific monoclonal antibodies with cytotoxic agents should overcome a number of limitations.
Similar articles
-
[Clinical applications of monoclonal antibodies].Rev Med Interne. 1985 Oct;6(4):403-10. doi: 10.1016/s0248-8663(85)80097-7. Rev Med Interne. 1985. PMID: 3906817 Review. French. No abstract available.
-
Monoclonal antibodies in diagnosis and treatment.Arch Dis Child. 1985 Feb;60(2):96-8. doi: 10.1136/adc.60.2.96. Arch Dis Child. 1985. PMID: 3883914 Free PMC article. No abstract available.
-
Monoclonal antibodies in the diagnosis and treatment of childhood diseases.Adv Pediatr. 1985;32:101-37. Adv Pediatr. 1985. PMID: 3909771 Review. No abstract available.
-
Effector cells of graft-versus-host disease, host resistance, and the graft-versus-leukemia effect: summary of a workshop on bone marrow transplantation.Transplant Proc. 1987 Feb;19(1 Pt 3):2758-61. Transplant Proc. 1987. PMID: 3547953 No abstract available.
-
CAMPATH-1 monoclonal antibodies in bone marrow transplantation.J Hematother. 1994 Spring;3(1):15-31. doi: 10.1089/scd.1.1994.3.15. J Hematother. 1994. PMID: 7922004 Clinical Trial.
Cited by
-
Infectious disease therapy in the 1990s. Where are we heading?Drugs. 1992 May;43(5):629-36. doi: 10.2165/00003495-199243050-00001. Drugs. 1992. PMID: 1379143 Review. No abstract available.
-
Monoclonal antibodies and immobilized antibodies. Patents and literature.Appl Biochem Biotechnol. 1987 Jun;15(1):53-80. doi: 10.1007/BF02798506. Appl Biochem Biotechnol. 1987. PMID: 3662496
-
Prospects for monoclonal antibodies in the diagnosis and treatment of bacterial infections.Eur J Clin Microbiol Infect Dis. 1990 Apr;9(4):247-50. doi: 10.1007/BF01968054. Eur J Clin Microbiol Infect Dis. 1990. PMID: 2190829 Review. No abstract available.