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Review
. 2024 Sep;37(5):1347-1354.
doi: 10.1007/s13577-024-01092-9. Epub 2024 Jun 10.

Targeted inhibition of SUMOylation: treatment of tumors

Hongwei Zhao  1 , Panpan Zhao  1 , Chao Huang  2
Affiliations
Review

Targeted inhibition of SUMOylation: treatment of tumors

Hongwei Zhao et al. Hum Cell. 2024 Sep.

Abstract

SUMOylation is a dynamic and reversible post-translational modification (PTM) of proteins involved in the regulation of biological processes such as protein homeostasis, DNA repair and cell cycle in normal and tumor cells. In particular, overexpression of SUMOylation components in tumor cells increases the activity of intracellular SUMOylation, protects target proteins against ubiquitination degradation and activation, promoting tumor cell proliferation and metastasis, providing immune evasion and increasing tolerance to chemotherapy and antitumor drugs. However, with the continuous research on SUMOylation and with the continued development of SUMOylation inhibitors, it has been found that tumor initiation and progression can be inhibited by blocking SUMOylation and/or in combination with drugs. SUMOylation is not a bad target when trying to treat tumor. This review introduces SUMOylation cycle pathway and summarizes the role of SUMOylation in tumor initiation and progression and SUMOylation inhibitors and their functions in tumors and provides a prospective view of SUMOylation as a new therapeutic target for tumors.

Keywords: SUMO family; SUMO proteases; SUMOylation; SUMOylation inhibitors; Tumor.

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