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Review
. 2024 Sep;40(9):747-756.
doi: 10.1016/j.tig.2024.05.008. Epub 2024 Jun 8.

Building the brain mosaic: an expanded view

Sahibjot Sran  1 , Amanda Ringland  1 , Tracy A Bedrosian  2
Affiliations
Review

Building the brain mosaic: an expanded view

Sahibjot Sran et al. Trends Genet. 2024 Sep.

Abstract

The complexity of the brain is closely tied to its nature as a genetic mosaic, wherein each cell is distinguished by a unique constellation of somatic variants that contribute to functional and phenotypic diversity. Postzygotic variation arising during neurogenesis is recognized as a key contributor to brain mosaicism; however, recent advances have broadened our understanding to include sources of neural genomic diversity that develop throughout the entire lifespan, from embryogenesis through aging. Moving beyond the traditional confines of neurodevelopment, in this review, we delve into the complex mechanisms that enable various origins of brain mosaicism.

Keywords: clonal lineages; development; embryogenesis; neurogenesis; selection, reversion.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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