Optimisation of vitamin D status in global populations

doi:10.1007/s00198-024-07127-z

Review

. 2024 Aug;35(8):1313-1322.

doi: 10.1007/s00198-024-07127-z. Epub 2024 Jun 5.

Optimisation of vitamin D status in global populations

N C Harvey^{1

2}, K A Ward^{3

4}, D Agnusdei⁵, N Binkley⁶, E Biver⁷, C Campusano⁸, E Cavalier⁹, P Clark¹⁰, M Diaz-Curiel¹¹, G E-H Fuleihan¹², P Khashayar¹³, N E Lane¹⁴, O D Messina¹⁵, A Mithal¹⁶, R Rizzoli¹⁷, C Sempos¹⁸, B Dawson-Hughes¹⁹; International Osteoporosis Foundation Vitamin D Working Group

Affiliations

¹ MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, SO16 6YD, UK. nch@mrc.soton.ac.uk.
² NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. nch@mrc.soton.ac.uk.
³ MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, SO16 6YD, UK.
⁴ NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁵ University of Siena, Siena, Italy.
⁶ University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁷ Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁸ Internal Medicine Department, Clínica Universidad de los Andes and Universidad de los Andes, Santiago, Chile.
⁹ Department of Clinical Chemistry, University of Liege, CIRM, CHU de Liège, Liège, Belgium.
¹⁰ Clinical Epidemiology Unit, Hospital Infantil Federico Gómez-Facultad de Medicina UNAM, Mexico, Mexico.
¹¹ Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain.
¹² Calcium Metabolism and Osteoporosis Program, Division of Endocrinology, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon.
¹³ International Institute for Biosensing, University of Minnesota, Minneapolis, USA.
¹⁴ Division of Rheumatology, Department of Medicine, U.C. Davis Health, Sacramento, CA, USA.
¹⁵ IRO Medical Research Centre, Collaborating Centre WHO, Buenos Aires, Argentina.
¹⁶ Institute of Endocrinology and Diabetes, Max Healthcare, Delhi, India.
¹⁷ Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
¹⁸ Vitamin D Standardization Program (VDSP), Havre de Grace, MD, USA.
¹⁹ Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

PMID: 38836946
DOI: 10.1007/s00198-024-07127-z

Free article

Review

Optimisation of vitamin D status in global populations

N C Harvey et al. Osteoporos Int. 2024 Aug.

Free article

. 2024 Aug;35(8):1313-1322.

doi: 10.1007/s00198-024-07127-z. Epub 2024 Jun 5.

Authors

Affiliations

¹ MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, SO16 6YD, UK. nch@mrc.soton.ac.uk.
² NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. nch@mrc.soton.ac.uk.
³ MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, SO16 6YD, UK.
⁴ NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
⁵ University of Siena, Siena, Italy.
⁶ University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
⁷ Division of Bone Diseases, Department of Medicine, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
⁸ Internal Medicine Department, Clínica Universidad de los Andes and Universidad de los Andes, Santiago, Chile.
⁹ Department of Clinical Chemistry, University of Liege, CIRM, CHU de Liège, Liège, Belgium.
¹⁰ Clinical Epidemiology Unit, Hospital Infantil Federico Gómez-Facultad de Medicina UNAM, Mexico, Mexico.
¹¹ Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain.
¹² Calcium Metabolism and Osteoporosis Program, Division of Endocrinology, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut, Beirut, Lebanon.
¹³ International Institute for Biosensing, University of Minnesota, Minneapolis, USA.
¹⁴ Division of Rheumatology, Department of Medicine, U.C. Davis Health, Sacramento, CA, USA.
¹⁵ IRO Medical Research Centre, Collaborating Centre WHO, Buenos Aires, Argentina.
¹⁶ Institute of Endocrinology and Diabetes, Max Healthcare, Delhi, India.
¹⁷ Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
¹⁸ Vitamin D Standardization Program (VDSP), Havre de Grace, MD, USA.
¹⁹ Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.

PMID: 38836946
DOI: 10.1007/s00198-024-07127-z

Abstract

Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering, season and supplement use. Whilst overt vitamin D deficiency with biochemical consequences presents an increased risk of severe sequelae such as rickets, osteomalacia or cardiomyopathy and usually warrants prompt replacement treatment, the role of vitamin D supplementation in the population presents a different set of considerations. Here the issue is to keep, on average, the population at a level whereby the risk of adverse health outcomes in the population is minimised. This position paper, which complements recently published work from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, addresses key considerations regarding vitamin D assessment and intervention from the population perspective. This position paper, on behalf of the International Osteoporosis Foundation Vitamin D Working Group, summarises the burden and possible amelioration of vitamin D deficiency in global populations. It addresses key issues including screening, supplementation and food fortification.

Keywords: Cholecalciferol; Deficiency; Ergocalciferol; Population; Supplementation; Vitamin D.

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References

1. Chevalley T, Brandi ML, Cashman KD et al (2022) Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clin Exp Res 34:2603–2623 - PubMed - PMC
1. Wahl DA, Cooper C, Ebeling PR et al (2012) A global representation of vitamin D status in healthy populations. Arch Osteoporos 7:155–172 - PubMed
1. Cashman KD (2022) Global differences in vitamin D status and dietary intake: a review of the data. Endocr Connect 11;11(1):e210282
1. Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanisms of action, and clinical applications. In: Favus MJ (ed) Primer on the metabolic bone diseases and mineral metabolism. ASBMR, Chicago, pp 106–114
1. Uday S, Hogler W (2019) Spot the silent sufferers: a call for clinical diagnostic criteria for solar and nutritional osteomalacia. J Steroid Biochem Mol Biol 188:141–146 - PubMed

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[1] Chevalley T, Brandi ML, Cashman KD et al (2022) Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clin Exp Res 34:2603–2623 - PubMed - PMC

[2] Chevalley T, Brandi ML, Cashman KD et al (2022) Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group. Aging Clin Exp Res 34:2603–2623 - PubMed - PMC

[3] Wahl DA, Cooper C, Ebeling PR et al (2012) A global representation of vitamin D status in healthy populations. Arch Osteoporos 7:155–172 - PubMed

[4] Wahl DA, Cooper C, Ebeling PR et al (2012) A global representation of vitamin D status in healthy populations. Arch Osteoporos 7:155–172 - PubMed

[5] Cashman KD (2022) Global differences in vitamin D status and dietary intake: a review of the data. Endocr Connect 11;11(1):e210282

[6] Cashman KD (2022) Global differences in vitamin D status and dietary intake: a review of the data. Endocr Connect 11;11(1):e210282

[7] Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanisms of action, and clinical applications. In: Favus MJ (ed) Primer on the metabolic bone diseases and mineral metabolism. ASBMR, Chicago, pp 106–114

[8] Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanisms of action, and clinical applications. In: Favus MJ (ed) Primer on the metabolic bone diseases and mineral metabolism. ASBMR, Chicago, pp 106–114

[9] Uday S, Hogler W (2019) Spot the silent sufferers: a call for clinical diagnostic criteria for solar and nutritional osteomalacia. J Steroid Biochem Mol Biol 188:141–146 - PubMed

[10] Uday S, Hogler W (2019) Spot the silent sufferers: a call for clinical diagnostic criteria for solar and nutritional osteomalacia. J Steroid Biochem Mol Biol 188:141–146 - PubMed

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Optimisation of vitamin D status in global populations

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Optimisation of vitamin D status in global populations

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