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. 2024 May 27:8:59-68.
doi: 10.15698/cst2024.05.297. eCollection 2024.

Saliva, a molecular reflection of the human body? Implications for diagnosis and treatment

Vincent Géli, Norbert Nabet

Saliva, a molecular reflection of the human body? Implications for diagnosis and treatment

Vincent Géli et al. Cell Stress. .

Abstract

For many diseases, and cancer in particular, early diagnosis allows a wider range of therapies and a better disease management. This has led to improvements in diagnostic procedures, most often based on tissue biopsies or blood samples. Other biological fluids have been used to diagnose disease, and among them saliva offers a number of advantages because it can be collected non-invasively from large populations at relatively low cost. To what extent might saliva content reveal the presence of a tumour located at a distance from the oral cavity and the molecular information obtained from saliva be used to establish a diagnosis are current questions. This review focuses primarily on the content of saliva and shows how it potentially offers a source of diagnosis, possibly at an early stage, for pathologies such as cancers or endometriosis.

Keywords: cancer; diagnosis; endometriosis; miRNA; saliva.

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Conflict of interest statement

From December 2023 to April 2024, V.G. was employed by the Ziwig Biotech company.

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