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Review
. 2024 Jun;598(12):1453-1464.
doi: 10.1002/1873-3468.14940. Epub 2024 May 29.

Decoding microtubule detyrosination: enzyme families, structures, and functional implications

Jitske Bak  1 , Thijn R Brummelkamp  1 , Anastassis Perrakis  1
Affiliations
Review

Decoding microtubule detyrosination: enzyme families, structures, and functional implications

Jitske Bak et al. FEBS Lett. 2024 Jun.

Abstract

Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of the C-terminal tyrosine of α-tubulin on assembled microtubules and the re-ligation of tyrosine on detyrosinated tubulin dimers. This modification cycle has been implicated in cardiac disease, neuronal development, and mitotic defects. The vasohibin and microtubule-associated tyrosine carboxypeptidase enzyme families are responsible for microtubule detyrosination. Their long-sought discovery allows to review and summarise differences and similarities between the two enzymes families and discuss how they interplay with other modifications and functions of the tubulin code.

Keywords: cytoskeleton; detyrosination; microtubules; modifications; tubulin code.

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