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Review
. 2024:1451:55-74.
doi: 10.1007/978-3-031-57165-7_4.

Characterization of Fowlpox Virus

Rajesh Kumar Verma  1 , A K Gangwar  2
Affiliations
Review

Characterization of Fowlpox Virus

Rajesh Kumar Verma et al. Adv Exp Med Biol. 2024.

Abstract

The complex cytoplasmic DNA virus known as the fowlpox virus (FWPV) is a member of the avipoxvirus genus, Subfamily Chordopoxvirinae, and Family Poxviridae. The large genome size of FWPV makes it a potential vector for the creation of vaccines against a range of serious veterinary and human ailments. It also allows for multiple gene insertion and the generation of abortive infection in mammalian cells. The virus, which causes fowlpox in chickens and turkeys, is mainly transmitted to poultry through aerosols or biting insects. Fowlpox is a highly contagious disease that affects both domestic and wild birds, causing cutaneous and/or diphtheritic illnesses. To control the illness, strict hygiene practices and immunization with FWPV attenuated strains or antigenically similar pigeon pox virus vaccines are employed. Recent years have seen an increase in fowlpox outbreaks in chicken flocks, primarily due to the introduction of novel forms of FWPV. It is believed that the pathogenic characteristics of these strains are enhanced by the integration of reticuloendotheliosis virus sequences of variable lengths into the FWPV genome. The standard laboratory diagnosis of FPV involves histopathological analysis, electron microscopy, virus isolation on chorioallantoic membrane (CAM) of embryonated chicken eggs or cell cultures, and serologic techniques. For quick and consistent diagnosis, polymerase chain reaction (PCR) has proven to be the most sensitive method. PCR is used in concert with restriction endonuclease enzyme analysis (REA) to identify, differentiate, and characterize the molecular makeup of isolates of the fowlpox virus. Sequencing of the amplified fragments is then done.

Keywords: Avian pox; Chorioallantoic membrane; Fowlpox; Polymerase chain reaction; Poxviridae; Reticuloendotheliosis virus.

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References

    1. Abdu PA, Musa U (2014) Textbook of Avian Medicine. 1st ed. P.A. Ndahi Printing, Sabon Gari, Zaria-Nigeria, pp 94–96
    1. Adams CJ, Feldman SH, Sleeman JM (2005) Phylogenetic analysis of avian poxviruses among free-ranging birds of Virginia. Avian Dis 49:601–605 - PubMed - DOI
    1. Afonso CL, Tulman ER, Lu Z, Zsak L, Kutish GF, Rock DL (2000) The genome of fowlpox virus. J Virol 2000(74):3815–3831 - DOI
    1. Akey BL, Nayer JK, Forrester DJ (1981) Avian pox in Florida wild turkeys: Culex nigripalpus and Wyeomyia vanduzeei as experimental vectors. J Wild L Dis 17(4):597–599 - DOI
    1. Alcami A (2007) New insights into the subversion of the chemokine system by poxviruses. Eur J Immunol 37:880–883 - PubMed - DOI

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