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Review
. 2024 Apr 29;27(6):109845.
doi: 10.1016/j.isci.2024.109845. eCollection 2024 Jun 21.

Manufacturing and validation of small-diameter vascular grafts: A mini review

Deyanira Hernandez-Sanchez  1 , Maxime Comtois-Bona  1 , Marcelo Muñoz  1 , Marc Ruel  1   2   3 , Erik J Suuronen  1   3 , Emilio I Alarcon  1   4
Affiliations
Review

Manufacturing and validation of small-diameter vascular grafts: A mini review

Deyanira Hernandez-Sanchez et al. iScience. .

Abstract

The field of small-diameter vascular grafts remains a challenge for biomaterials scientists. While decades of research have brought us much closer to developing biomimetic materials for regenerating tissues and organs, the physiological challenges involved in manufacturing small conduits that can transport blood while not inducing an immune response or promoting blood clots continue to limit progress in this area. In this short review, we present some of the most recent methods and advancements made by researchers working in the field of small-diameter vascular grafts. We also discuss some of the most critical aspects biomaterials scientists should consider when developing lab-made small-diameter vascular grafts.

Keywords: Bioengineering; Biomaterials; Cardiovascular medicine; Tissue engineering.

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Conflict of interest statement

The authors declare no competing interests.

Figures

None
Graphical abstract
Figure 1
Figure 1
Graphical summary of the manufacturing methods for small vascular grafts (A) Electrospinning. (B) 3D printing. (C) Molding. (D) Decellularization. (E) In vivo maturation.
Figure 2
Figure 2
Physical dimensions of the engineered small vascular grafts discussed in this review (A) Inside and outside diameter (mm). (B) Length (mm). Values in plots are depicted in boxplots, where the box encloses 50% of the data and the upper and lower quartiles, with the median value of the variable displayed as a line inside the box.
Figure 3
Figure 3
Burst pressure plot of the different categories of vascular grafts Electrospun (Electro), in vivo maturation (in vivo), 3D printing, molding, decellularization (Decel.), and autologous vessels (Autologous). Values in plots are depicted in boxplots, where the box encloses 50% of the data and the upper and lower quartiles, with the median value of the variable displayed as a line inside the box.
Figure 4
Figure 4
In vivo assessment of the discussed grafts (A) Animal models used for the in vivo assessment of the reviewed engineered small vascular grafts. (B) Follow-up periods of the in vivo experiments for the articles reviewed in this mini review. Values in B are depicted in boxplots, where the box encloses 50% of the data and the upper and lower quartiles, with the median value of the variable displayed as a line inside the box.
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