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Review
. 2024 Sep:78:101906.
doi: 10.1016/j.mito.2024.101906. Epub 2024 May 24.

Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways

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Review

Cell-penetrating peptides with nanoparticles hybrid delivery vectors and their uptake pathways

Moataz Dowaidar. Mitochondrion. 2024 Sep.

Abstract

Cell-penetrating peptides (CPPs) are molecules that improve the cellular uptake of various molecular payloads that do not easily traverse the cellular membrane. CPPs can be found in pharmaceutical and medical products. The vast majority of cell-penetrating chemicals that are discussed in published research are peptide based. The paper also delves into the various applications of hybrid vectors. Because CPPs are able to carry cargo across the cellular membrane, they are a viable candidate for use as a suitable carrier for a wide variety of cargoes, such as siRNA, nanoparticles, and others. In which we discuss the CPPs, their classification, uptake mechanisms, hybrid vector systems, nanoparticles and their uptake mechanisms, etc. Further in this paper, we discuss CPPs conjugated to Nanoparticles, Combining CPPs with lipids and polymeric Nanoparticles in A Conjugated System, CPPs conjugated to nanoparticles for therapeutic purposes, and potential therapeutic uses of CPPs as delivery molecules. Also discussed the preclinical and clinical use of CPPS, intracellular trafficking of nanoparticles, and activatable and bioconjugated CPPs.

Keywords: CPPs; Cell-Penetrating Peptides; Drug Delivery Systems; Endocytosis Mechanisms; Hybrid Delivery Vectors; Intracellular Uptake; Nanoparticle-CPP Conjugates; Nanoparticles; Nanotechnology in Medicine; Targeted Drug Delivery; Therapeutic Nanocarriers.

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