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Review
. 2024 Jun:97:101282.
doi: 10.1016/j.mam.2024.101282. Epub 2024 May 25.

Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis

Kei-Ichiro Ishiguro  1
Affiliations
Free article
Review

Mechanisms of meiosis initiation and meiotic prophase progression during spermatogenesis

Kei-Ichiro Ishiguro. Mol Aspects Med. 2024 Jun.
Free article

Abstract

Meiosis is a critical step for spermatogenesis and oogenesis. Meiosis commences with pre-meiotic S phase that is subsequently followed by meiotic prophase. The meiotic prophase is characterized by the meiosis-specific chromosomal events such as chromosome recombination and homolog synapsis. Meiosis initiator (MEIOSIN) and stimulated by retinoic acid gene 8 (STRA8) initiate meiosis by activating the meiotic genes by installing the meiotic prophase program at pre-meiotic S phase. This review highlights the mechanisms of meiotic initiation and meiotic prophase progression from the point of the gene expression program and its relevance to infertility. Furthermore, upstream pathways that regulate meiotic initiation will be discussed in the context of spermatogenic development, indicating the sexual differences in the mode of meiotic entry.

Keywords: Cell cycle; Chromosome; Gene expression; Meiosis; Spermatogenesis.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflicts of interests.

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