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. 2024 May 23;19(5):e0302682.
doi: 10.1371/journal.pone.0302682. eCollection 2024.

Maternal COVID-19 exposure and placental characteristics

Ghassan Allo  1   2 , Alexandra R Sitarik  3 , Ashley Redding  3 , Chad M Coleman  3 , Andrea E Cassidy-Bushrow  3 , Arthur Gaba  1 , Jennifer K Straughen  2   3
Affiliations

Maternal COVID-19 exposure and placental characteristics

Ghassan Allo et al. PLoS One. .

Abstract

Introduction: The impact of COVID-19 on the placenta is poorly described, particularly among minority women.

Materials and methods: This is a retrospective case-control study. Micro- and macroscopic placental pathologic findings were compared for 15 COVID-19 positive and 36 negative mothers. Cases and controls were frequency matched on gestational age, race, maternal comorbidities, and delivery type. Data from the electronic medical record were supplemented with independent review of microscopic slides.

Results: Placentas from cases and controls were similar except the median distance from the site of the cord insertion to the nearest disk margin was statistically significantly shorter among placentas from COVID-19 positive cases (3.5 versus 6.0 cm, p = 0.006). Case status was not associated with an increased risk of placental pathologies.

Conclusion: There are few pathologic differences between placentas of COVID-19 positive and negative mothers. Additional studies are needed to investigate the role of timing of infection.

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Conflict of interest statement

The authors have declared that no competing interests exist.

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References

    1. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al.. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–74. doi: 10.1016/S0140-6736(20)30251-8 - DOI - PMC - PubMed
    1. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782–93. doi: 10.1001/jama.2020.12839 - DOI - PubMed
    1. Fenizia C, Biasin M, Cetin I, Vergani P, Mileto D, Spinillo A, et al.. Analysis of SARS-CoV-2 vertical transmission during pregnancy. Nat Commun. 2020;11(1):5128. doi: 10.1038/s41467-020-18933-4 - DOI - PMC - PubMed
    1. Hecht JL, Quade B, Deshpande V, Mino-Kenudson M, Ting DT, Desai N, et al.. SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers. Mod Pathol. 2020;33(11):2092–103. doi: 10.1038/s41379-020-0639-4 - DOI - PMC - PubMed
    1. Hsu AL, Guan M, Johannesen E, Stephens AJ, Khaleel N, Kagan N, et al.. Placental SARS-CoV-2 in a pregnant woman with mild COVID-19 disease. J Med Virol. 2021;93(2):1038–44. doi: 10.1002/jmv.26386 - DOI - PMC - PubMed

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The authors received no specific funding for this work.