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. 2024 Oct;4(4):69-75.
doi: 10.47936/encephalitis.2024.00017. Epub 2024 May 21.

The relationship between sleep and innate immunity

Yoonkyung Lee  1 , Kyung-Il Park  2   3
Affiliations

The relationship between sleep and innate immunity

Yoonkyung Lee et al. Encephalitis. 2024 Oct.

Abstract

Sleep regulates inflammatory responses, and the innate immune system affects sleep. Interleukin-1 beta, tumor necrosis factor alpha, growth hormone-releasing hormone, prolactin, and nitric oxide are somnogenic substances. Sleep deprivation, such as chronic insomnia or obstructive sleep apnea, affects cytokine production, glial function, natural killer cell activity, and inflammasome function. This review will discuss the relationship between sleep and innate immunity.

Keywords: Cytokines; Inflammation; Innate immunity; Microglia; Sleep.

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Conflict of interest statement

Conflicts of Interest

Kyung-Il Park has been the Editor-in-Chief of encephalitis, and he was not involved in the review process of this article. No other potential conflict of interest relevant to this article was reported.

Figures

Figure 1.
Figure 1.. The relationship between sleep and innate immunity
Sleep and innate immunity regulate each other and show a reciprocal relationship. Sleep is regulated by glia, cytokines, and inflammatory pathways. The immune system is influenced by sleep disturbances. NK cell, natural killer cell; IL, interleukin; TNF, tumor necrosis factor; NREM, non-rapid eye movement; REM, rapid eye movement; NF-κB, nuclear factor kappa B; NO, nitric oxide; COX, cyclooxygenase; NOD, nucleotide-binding oligomerization domain.
See this image and copyright information in PMC

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References

    1. Zielinski MR, Krueger JM. Sleep and innate immunity. Front Biosci (Schol Ed) 2011;3:632–642. - PMC - PubMed
    1. Bryant PA, Trinder J, Curtis N. Sick and tired: does sleep have a vital role in the immune system? Nat Rev Immunol. 2004;4:457–467. - PubMed
    1. Kubota K. Kuniomi Ishimori and the first discovery of sleep-inducing substances in the brain. Neurosci Res. 1989;6:497–518. - PubMed
    1. Jerigova V, Zeman M, Okuliarova M. Circadian disruption and consequences on innate immunity and inflammatory response. Int J Mol Sci. 2022;23:13722. - PMC - PubMed
    1. Gamaldo CE, Shaikh AK, McArthur JC. The sleep-immunity relationship. Neurol Clin. 2012;30:1313–1343. - PubMed

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