Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 2:15:1319863.
doi: 10.3389/fimmu.2024.1319863. eCollection 2024.

The immunomodulatory mechanism of acupuncture treatment for ischemic stroke: research progress, prospects, and future direction

Hongjun Kuang  1 , Xinzhou Zhu  2   3 , Huan Chen  4 , Han Tang  1 , Hong Zhao  1
Affiliations
Review

The immunomodulatory mechanism of acupuncture treatment for ischemic stroke: research progress, prospects, and future direction

Hongjun Kuang et al. Front Immunol. .

Erratum in

Abstract

Ischemic stroke (IS) is one of the leading causes of death and disability. Complicated mechanisms are involved in the pathogenesis of IS. Immunomodulatory mechanisms are crucial to IS. Acupuncture is a traditional non-drug treatment that has been extensively used to treat IS. The exploration of neuroimmune modulation will broaden the understanding of the mechanisms underlying acupuncture treatment. This review summarizes the immune response of immune cells, immune cytokines, and immune organs after an IS. The immunomodulatory mechanisms of acupuncture treatment on the central nervous system and peripheral immunity, as well as the factors that influence the effects of acupuncture treatment, were summarized. We suggest prospects and future directions for research on immunomodulatory mechanisms of acupuncture treatment for IS based on current progress, and we hope that these will provide inspiration for researchers. Additionally, acupuncture has shown favorable outcomes in the treatment of immune-based nervous system diseases, generating new directions for research on possible targets and treatments for immune-based nervous system diseases.

Keywords: acupuncture treatment; future direction; immunomodulatory mechanism; ischemic stroke; prospects; research progress.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The regulation of microglia in the central nervous system by acupuncture treatment for the treatment of ischemic stroke through multiple targets.
Figure 2
Figure 2
Central and peripheral immune modulation by acupuncture treatment for the treatment of ischemic stroke.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Feske SK. Ischemic stroke. Am J Med. (2021) 134:1457–64. doi: 10.1016/j.amjmed.2021.07.027 - DOI - PubMed
    1. GBD 2019 Stroke Collaborators . Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. (2021) 20:795–820. doi: 10.1016/s1474-4422(21)00252-0 - DOI - PMC - PubMed
    1. Cerniauskaite M, Quintas R, Koutsogeorgou E, Meucci P, Sattin D, Leonardi M, et al. . Quality-of-life and disability in patients with stroke. Am J Phys Med rehabilitation. (2012) 91:S39–47. doi: 10.1097/PHM.0b013e31823d4df7 - DOI - PubMed
    1. De Doncker W, Dantzer R, Ormstad H, Kuppuswamy A. Mechanisms of poststroke fatigue. J neurology neurosurgery Psychiatry. (2018) 89:287–93. doi: 10.1136/jnnp-2017-316007 - DOI - PubMed
    1. Yang S, Chang MC. Poststroke pain. Semin neurology. (2021) 41:67–74. doi: 10.1055/s-0040-1722641 - DOI - PubMed

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Shenzhen Science and Technology Program (Grant Numbers JCYJ20220818100803007 and JCYJ20210324120804012).