Effectiveness and safety of granulocyte colony-stimulating factor priming regimen for acute myeloid leukemia: A systematic review and meta-analysis of the Clinical Practice Guideline for the use of G-CSF 2022 from the Japan Society of Clinical Oncology

doi:10.1007/s10147-023-02461-4

Meta-Analysis

. 2024 Jul;29(7):899-910.

doi: 10.1007/s10147-023-02461-4. Epub 2024 May 17.

Effectiveness and safety of granulocyte colony-stimulating factor priming regimen for acute myeloid leukemia: A systematic review and meta-analysis of the Clinical Practice Guideline for the use of G-CSF 2022 from the Japan Society of Clinical Oncology

Yuho Najima¹, Tomoya Maeda², Yutaro Kamiyama³, Shinji Nakao⁴, Yukinori Ozaki⁵, Hiroshi Nishio⁶, Kenji Tsuchihashi⁷, Eiki Ichihara⁸, Yuji Miumra⁹, Makoto Endo¹⁰, Dai Maruyama¹¹, Tetsuhiro Yoshinami¹², Nobuyuki Susumu¹³, Munetaka Takekuma¹⁴, Takashi Motohashi¹⁵, Mamoru Ito⁷, Eishi Baba¹⁶, Nobuaki Ochi¹⁷, Toshio Kubo¹⁸, Keita Uchino¹⁹, Takahiro Kimura²⁰, Shinobu Tamura²¹, Hitomi Nishimoto²², Yasuhisa Kato²³, Atsushi Sato²⁴, Toshimi Takano⁵, Shingo Yano³

Affiliations

¹ Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-8-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8677, Japan. yuhonajima@gmail.com.
² Department of Hemato-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
³ Department of Clinical Oncology/Hematology, The Jikei University School of Medicine, Tokyo, Japan.
⁴ Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
⁵ Department of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
⁶ Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
⁷ Department of Hematology, Oncology and Cardiovascular Medicine, Fukuoka, Japan.
⁸ Center for Clinical Oncology, Okayama University Hospital, Okayama, Japan.
⁹ Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
¹⁰ Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.
¹¹ Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
¹² Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
¹³ Department of Obstetrics and Gynecology, International University of Health and Welfare Narita Hospital, Chiba, Japan.
¹⁴ Department of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
¹⁵ Department of Obstetrics and Gynecology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
¹⁶ Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹⁷ Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.
¹⁸ Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
¹⁹ Department of Medical Oncology, NTT Medical Center Tokyo, Tokyo, Japan.
²⁰ Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
²¹ Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
²² Department of Nursing, Okayama University Hospital, Okayama, Japan.
²³ Department of Drug Information, Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences, Kanagawa, Japan.
²⁴ Department of Medical Oncology, Hirosaki University Graduate School of Medicine, Aomori, Japan.

PMID: 38755516
DOI: 10.1007/s10147-023-02461-4

Meta-Analysis

Effectiveness and safety of granulocyte colony-stimulating factor priming regimen for acute myeloid leukemia: A systematic review and meta-analysis of the Clinical Practice Guideline for the use of G-CSF 2022 from the Japan Society of Clinical Oncology

Yuho Najima et al. Int J Clin Oncol. 2024 Jul.

. 2024 Jul;29(7):899-910.

doi: 10.1007/s10147-023-02461-4. Epub 2024 May 17.

Authors

Affiliations

¹ Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-8-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8677, Japan. yuhonajima@gmail.com.
² Department of Hemato-Oncology, Saitama Medical University International Medical Center, Saitama, Japan.
³ Department of Clinical Oncology/Hematology, The Jikei University School of Medicine, Tokyo, Japan.
⁴ Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Ishikawa, Japan.
⁵ Department of Breast Medical Oncology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
⁶ Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
⁷ Department of Hematology, Oncology and Cardiovascular Medicine, Fukuoka, Japan.
⁸ Center for Clinical Oncology, Okayama University Hospital, Okayama, Japan.
⁹ Department of Medical Oncology, Toranomon Hospital, Tokyo, Japan.
¹⁰ Department of Orthopaedic Surgery, Kyushu University, Fukuoka, Japan.
¹¹ Department of Hematology Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
¹² Department of Breast and Endocrine Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
¹³ Department of Obstetrics and Gynecology, International University of Health and Welfare Narita Hospital, Chiba, Japan.
¹⁴ Department of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan.
¹⁵ Department of Obstetrics and Gynecology, Tokyo Women's Medical University Hospital, Tokyo, Japan.
¹⁶ Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹⁷ Department of General Internal Medicine 4, Kawasaki Medical School, Okayama, Japan.
¹⁸ Department of Allergy and Respiratory Medicine, Okayama University Hospital, Okayama, Japan.
¹⁹ Department of Medical Oncology, NTT Medical Center Tokyo, Tokyo, Japan.
²⁰ Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
²¹ Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
²² Department of Nursing, Okayama University Hospital, Okayama, Japan.
²³ Department of Drug Information, Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences, Kanagawa, Japan.
²⁴ Department of Medical Oncology, Hirosaki University Graduate School of Medicine, Aomori, Japan.

PMID: 38755516
DOI: 10.1007/s10147-023-02461-4

Abstract

Background: The outcomes of relapsed or refractory acute myeloid leukemia (AML) remain poor. Although the concomitant use of granulocyte colony-stimulating factor (G-CSF) and anti-chemotherapeutic agents has been investigated to improve the antileukemic effect on AML, its usefulness remains controversial. This study aimed to investigate the effects of G-CSF priming as a remission induction therapy or salvage chemotherapy.

Methods: We performed a thorough literature search for studies related to the priming effect of G-CSF using PubMed, Ichushi-Web, and the Cochrane Library. A qualitative analysis of the pooled data was performed, and risk ratios (RRs) with confidence intervals (CIs) were calculated and summarized.

Results: Two reviewers independently extracted and accessed the 278 records identified during the initial screening, and 62 full-text articles were assessed for eligibility in second screening. Eleven studies were included in the qualitative analysis and 10 in the meta-analysis. A systematic review revealed that priming with G-CSF did not correlate with an improvement in response rate and overall survival (OS). The result of the meta-analysis revealed the tendency for lower relapse rate in the G-CSF priming groups without inter-study heterogeneity [RR, 0.91 (95% CI 0.82-1.01), p = 0.08; I² = 4%, p = 0.35]. In specific populations, including patients with intermediate cytogenetic risk and those receiving high-dose cytarabine, the G-CSF priming regimen prolonged OS.

Conclusions: G-CSF priming in combination with intensive remission induction treatment is not universally effective in patients with AML. Further studies are required to identify the patient cohort for which G-CSF priming is recommended.

Keywords: Acute myeloid leukemia; G-CSF; Meta-analysis; Priming effect.

PubMed Disclaimer

References

1. Döhner H, Weisdorf DJ, Bloomfield CD (2015) Acute myeloid leukemia. N Engl J Med 373(12):1136–1152. https://doi.org/10.1056/NEJMra1406184 - DOI - PubMed
1. Ishikawa F, Yoshida S, Saito Y et al (2007) Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25(11):1315–1321. https://doi.org/10.1038/nbt1350 - DOI - PubMed
1. Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367(6464):645–648. https://doi.org/10.1038/367645a0 - DOI - PubMed
1. Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730–737. https://doi.org/10.1038/nm0797-730 - DOI - PubMed
1. Akiyama N, Okamura T, Yoshida M et al (2022) Difference of compliance rates for the recommendations in Japanese Guideline on Febrile Neutropenia according to respondents’ attributes: the second report on a questionnaire survey among hematology-oncology physicians and surgeons. Support Care Cancer 30(5):4327–4336. https://doi.org/10.1007/s00520-022-06834-9 - DOI - PubMed - PMC

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information

[1] Döhner H, Weisdorf DJ, Bloomfield CD (2015) Acute myeloid leukemia. N Engl J Med 373(12):1136–1152. https://doi.org/10.1056/NEJMra1406184 - DOI - PubMed

[2] Döhner H, Weisdorf DJ, Bloomfield CD (2015) Acute myeloid leukemia. N Engl J Med 373(12):1136–1152. https://doi.org/10.1056/NEJMra1406184 - DOI - PubMed

[3] Ishikawa F, Yoshida S, Saito Y et al (2007) Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25(11):1315–1321. https://doi.org/10.1038/nbt1350 - DOI - PubMed

[4] Ishikawa F, Yoshida S, Saito Y et al (2007) Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol 25(11):1315–1321. https://doi.org/10.1038/nbt1350 - DOI - PubMed

[5] Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367(6464):645–648. https://doi.org/10.1038/367645a0 - DOI - PubMed

[6] Lapidot T, Sirard C, Vormoor J et al (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367(6464):645–648. https://doi.org/10.1038/367645a0 - DOI - PubMed

[7] Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730–737. https://doi.org/10.1038/nm0797-730 - DOI - PubMed

[8] Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730–737. https://doi.org/10.1038/nm0797-730 - DOI - PubMed

[9] Akiyama N, Okamura T, Yoshida M et al (2022) Difference of compliance rates for the recommendations in Japanese Guideline on Febrile Neutropenia according to respondents’ attributes: the second report on a questionnaire survey among hematology-oncology physicians and surgeons. Support Care Cancer 30(5):4327–4336. https://doi.org/10.1007/s00520-022-06834-9 - DOI - PubMed - PMC

[10] Akiyama N, Okamura T, Yoshida M et al (2022) Difference of compliance rates for the recommendations in Japanese Guideline on Febrile Neutropenia according to respondents’ attributes: the second report on a questionnaire survey among hematology-oncology physicians and surgeons. Support Care Cancer 30(5):4327–4336. https://doi.org/10.1007/s00520-022-06834-9 - DOI - PubMed - PMC

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Effectiveness and safety of granulocyte colony-stimulating factor priming regimen for acute myeloid leukemia: A systematic review and meta-analysis of the Clinical Practice Guideline for the use of G-CSF 2022 from the Japan Society of Clinical Oncology

Affiliations

Effectiveness and safety of granulocyte colony-stimulating factor priming regimen for acute myeloid leukemia: A systematic review and meta-analysis of the Clinical Practice Guideline for the use of G-CSF 2022 from the Japan Society of Clinical Oncology

Authors

Affiliations

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Abstract

Similar articles

References

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Medical