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Review
. 2024 Apr 24;13(9):2488.
doi: 10.3390/jcm13092488.

Bioactive Dressing: A New Algorithm in Wound Healing

Gianmarco Polverino  1 , Francesca Russo  1 , Francesco D'Andrea  1
Affiliations
Review

Bioactive Dressing: A New Algorithm in Wound Healing

Gianmarco Polverino et al. J Clin Med. .

Abstract

Wound management presents a significant global challenge, necessitating a comprehensive understanding of wound care products and clinical expertise in selecting dressings. Bioactive dressings (BD) represent a diverse category of dressings, capable of influencing wound healing through various mechanisms. These dressings, including honey, hyaluronic acid, collagen, alginates, and polymers enriched with polyhexamethylene biguanide, chitin, and chitosan derivatives, create a conducive environment for healing, promoting moisture balance, pH regulation, oxygen permeability, and fluid management. Interactive dressings further enhance targeted action by serving as substrates for bioactive agents. The continuous evolution of BDs, with new products introduced annually, underscores the need for updated knowledge in wound care. To facilitate dressing selection, a practical algorithm considers wound exudate, infection probability, and bleeding, guiding clinicians through the process. This algorithm aims to optimize wound care by ensuring the appropriate selection of BDs tailored to individual patient needs, ultimately improving outcomes in wound management.

Keywords: angiogenesis; bioactive dressing; inflammation; plastic surgery; skin; stem cells; wound healing; wounds.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
A new practical algorithm in approaching challenging wounds. PHMB: Polymers enriched with polyhexamethylene biguanide, HA: Hyaluronic acid, MMPs inhibitors: Matrix metalloproteinase inhibitors, PDRN: Polydeoxyribonucleotide.
See this image and copyright information in PMC

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