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Review
. 2024 May 8;150(5):243.
doi: 10.1007/s00432-024-05755-w.

Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

Affiliations
Review

Role played by MDSC in colitis-associated colorectal cancer and potential therapeutic strategies

Kang Wang et al. J Cancer Res Clin Oncol. .

Abstract

Colitis-associated colorectal cancer has been a hot topic in public health issues worldwide. Numerous studies have demonstrated the significance of myeloid-derived suppressor cells (MDSCs) in the progression of this ailment, but the specific mechanism of their role in the transformation of inflammation to cancer is unclear, and potential therapies targeting MDSC are also unclear. This paper outlines the possible involvement of MDSC to the development of colitis-associated colorectal cancer. It also explores the immune and other relevant roles played by MDSC, and collates relevant targeted therapies against MDSC. In addition, current targeted therapies for colorectal cancer are analyzed and summarized.

Keywords: CRC; Colitis-associated colorectal cancer; MDSC; Targeting strategies.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig.1
Fig.1
MDSC exerts relevant immunosuppressive functions in the inflammatory microenvironment and influences tumor development. Associated chemokines (CSF, VEGF, CXCLx, etc.) recruit MDSC in the inflammatory microenvironment; MDSC play an immunosuppressive role by inhibiting T-cell-associated functions; MDSC promote the involvement of Treg cells in the associated suppression of anti-tumor immune responses; MDSC promote epithelial-mesenchymal transition (EMT), tumor angiogenesis, and enhancement of tumor cell stemness

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