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Review
. 2024 Jul:121:102875.
doi: 10.1016/j.ceca.2024.102875. Epub 2024 Apr 20.

The tether function of the anoctamins

Wei-Yin Lin  1 , Woo Young Chung  1 , Shmuel Muallem  1
Affiliations
Review

The tether function of the anoctamins

Wei-Yin Lin et al. Cell Calcium. 2024 Jul.

Abstract

The core functions of the anoctamins are Cl- channel activity and phosphatidylserine (and perhaps other lipids) scrambling. These functions have been extensively studied in various tissues and cells. However, another function of the anoctamins that is less recognized and minimally explored is as tethers at membrane contact sites. This short review aims to examine evidence supporting the localization of the anoctamins at membrane contact sites, their tether properties, and their functions as tethers.

Keywords: Anoctamins; Tethers.

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Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

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