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. 2024 Apr 18;13(8):2358.
doi: 10.3390/jcm13082358.

Data-Driven Surveillance Protocol for Patients at Risk for Peritoneal Recurrence of Primary Colon Cancer: Surveillance for Peritoneal Carcinomatosis

Meloria A Hoskins  1 , Adam Finkelstein  1 , Aisha Rashid  1 , Olivia Ziegler  2 , Marc M Mankarious  2 , Jorge V Benavides  3 , Colette R Pameijer  3
Affiliations

Data-Driven Surveillance Protocol for Patients at Risk for Peritoneal Recurrence of Primary Colon Cancer: Surveillance for Peritoneal Carcinomatosis

Meloria A Hoskins et al. J Clin Med. .

Abstract

Peritoneal carcinomatosis (PC) is rarely discovered early due to low sensitivity of screening imaging and tumor markers, however, earlier identification may improve outcomes. This study assesses risk factors and time to recurrence of PC and implementation of a surveillance system. Patients with stage II-III colon adenocarcinoma undergoing curative colectomy between 2005-2022 were retrospectively reviewed at a single tertiary care institution. Patients were divided into three cohorts: no recurrence (NR), PC, and other types of recurrence (OTR). Baseline characteristics between cohorts were compared with univariate analysis. Overall survival and PC risk were assessed using multivariate analysis with Cox's proportional-hazard modelling. 412 patients were included; 78.4% had NR, 7.8% had PC, and 13.8% had OTR. Patient demographics, comorbidities, tumor side, and histologic features were similar between cohorts. Patients with PC were more likely to have microscopic tumor perforation (25% vs. 8.8% vs. 6.8%, p = 0.002), margin involvement (25% vs. 8.8% vs. 4.6%, p < 0.001), lymphovascular invasion (56.2% vs. 33.3%, vs. 24.5%, p < 0.001), perineural invasion (28.1% vs. 15.8% vs. 11.5%, p = 0.026) compared to OTR or NR. Median time to PC after colectomy was 11 months. Tumor characteristics of stage II-III colon cancer define a high-risk profile for PC. An early surveillance program sensitive for peritoneal disease should be adopted for these patients.

Keywords: carcinomatosis; colorectal neoplasms; peritoneal neoplasms; recurrence.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Kaplan Meier estimates for overall survival after resection of stage II–III colon cancer. Abbreviations: NR: No recurrence; OR: Other recurrence; PC: peritoneal carcinomatosis. Dotted line indicates median survival.
Figure 2
Figure 2
Kaplan Meier estimates for recurrence after surgical resection. Abbreviations: Other: Other recurrence; PC: peritoneal carcinomatosis. Dotted line indicates median survival.
See this image and copyright information in PMC

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