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Review
. 2024 Jun;44(6):1191-1201.
doi: 10.1161/ATVBAHA.124.320851. Epub 2024 Apr 25.

Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties

Laura Atehortua  1 , W Sean Davidson  2 , Claire A Chougnet  1
Affiliations
Review

Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties

Laura Atehortua et al. Arterioscler Thromb Vasc Biol. 2024 Jun.

Abstract

Several studies in animal models and human cohorts have recently suggested that HDLs (high-density lipoproteins) not only modulate innate immune responses but also adaptative immune responses, particularly CD4+ T cells. CD4+ T cells are central effectors and regulators of the adaptive immune system, and any alterations in their homeostasis contribute to the pathogenesis of cardiovascular diseases, autoimmunity, and inflammatory diseases. In this review, we focus on how HDLs and their components affect CD4+ T-cell homeostasis by modulating cholesterol efflux, immune synapsis, proliferation, differentiation, oxidative stress, and apoptosis. While the effects of apoB-containing lipoproteins on T cells have been relatively well established, this review focuses specifically on new connections between HDL and CD4+ T cells. We present a model where HDL may modulate T cells through both direct and indirect mechanisms.

Keywords: T lymphocytes; cardiovascular diseases; homeostasis; inflammation; lipoproteins, HDL.

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Conflict of interest statement

Disclosures None.

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References

    1. Trakaki A, Marsche G. Current Understanding of the Immunomodulatory Activities of High-Density Lipoproteins. Biomedicines. 2021;9. doi: 10.3390/biomedicines9060587 - DOI - PMC - PubMed
    1. Catapano AL, Pirillo A, Bonacina F, Norata GD. HDL in innate and adaptive immunity. Cardiovasc Res. 2014;103:372–383. doi: 10.1093/cvr/cvu150 - DOI - PubMed
    1. Thomson R, Samanovic M, Raper J. Activity of trypanosome lytic factor: a novel component of innate immunity. Future Microbiol. 2009;4:789–796. doi: 10.2217/fmb.09.57 - DOI - PMC - PubMed
    1. Weng W, Breslow JL. Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc Natl Acad Sci U S A. 1996;93:14788–14794. doi: 10.1073/pnas.93.25.14788 - DOI - PMC - PubMed
    1. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Chan L, Oka K, et al. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009;29:843–849. doi: 10.1161/atvbaha.108.183442 - DOI - PMC - PubMed

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