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Review
. 2024 Apr 19;384(6693):eadl2016.
doi: 10.1126/science.adl2016. Epub 2024 Apr 19.

Interferon- γ and infectious diseases: Lessons and prospects

Jean-Laurent Casanova #  1   2   3   4   5 , John D MacMicking #  6   7   8   9 , Carl F Nathan #  10
Affiliations
Review

Interferon- γ and infectious diseases: Lessons and prospects

Jean-Laurent Casanova et al. Science. .

Abstract

Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from these diseases would benefit not just from new medicines and vaccines but also from a better understanding of what constitutes protective immunity. Among the major immune signals that mobilize host defense against infection is interferon-γ (IFN-γ), a protein secreted by lymphocytes. Forty years ago, IFN-γ was identified as a macrophage-activating factor, and, in recent years, there has been a resurgent interest in IFN-γ biology and its role in human defense. Here we assess the current understanding of IFN-γ, revisit its designation as an "interferon," and weigh its prospects as a therapeutic against globally pervasive microbial pathogens.

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