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Review
. 2024 Mar 19;7(4):967-990.
doi: 10.1021/acsptsci.4c00008. eCollection 2024 Apr 12.

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Neelakanta Sarvashiva Kiran  1 , Chandrashekar Yashaswini  1 , Rahul Maheshwari  2 , Sankha Bhattacharya  3 , Bhupendra G Prajapati  4
Affiliations
Review

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies

Neelakanta Sarvashiva Kiran et al. ACS Pharmacol Transl Sci. .

Abstract

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized and effective disease management. Identification of key driver mutations and molecular profiling have deepened our comprehension of the genetic alterations in colorectal cancer, facilitating targeted therapy and immunotherapy selection. Biomarkers such as microsatellite instability (MSI) and DNA mismatch repair deficiency (dMMR) guide treatment decisions, opening avenues for immunotherapy. Emerging technologies such as liquid biopsies, artificial intelligence, and machine learning promise to revolutionize early detection, monitoring, and treatment selection in precision medicine. Despite these advancements, ethical and regulatory challenges, including equitable access and data privacy, emphasize the importance of responsible implementation. The dynamic nature of colorectal cancer, with its tumor heterogeneity and clonal evolution, underscores the necessity for adaptive and personalized treatment strategies. The future of precision medicine in colorectal cancer lies in its potential to enhance patient care, clinical outcomes, and our understanding of this intricate disease, marked by ongoing evolution in the field. The current reviews focus on providing in-depth knowledge on the various and diverse approaches utilized for precision medicine against colorectal cancer, at both molecular and biochemical levels.

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Conflict of interest statement

The authors declare no competing financial interest.

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References

    1. Amalinei C.; Pricope D.-L.; Grigoras A. Colorectal cancer stem cells: overview and potential targeted therapy. Cancer Stem Cells and Signaling Pathways 2024, 185–205. 10.1016/B978-0-443-13212-4.00018-0. - DOI
    1. Dohrn N.; Klein M. F. Colorectal cancer: current management and future perspectives. British Journal of Surgery 2023, 110, 1256.10.1093/bjs/znad095. - DOI - PubMed
    1. Anugwom C.; Braimoh G.; Sultan A.; Johnson W. M.; Debes J. D.; Mohammed A. In Epidemiology and genetics of early onset colorectal cancer—African overview with a focus on Ethiopia; Elsevier: 2023.10.1053/j.seminoncol.2023.03.007 - DOI - PubMed
    1. Lin Y.; Zhao Z.; Nie W.; Huang M.; Cai J.; Wang Y.; Wang H.; Huang Y.; Bai Y. Overview of distinct 5-methylcytosine profiles of messenger RNA in normal and knock-down NSUN2 colorectal cancer cells. Frontiers in Genetics 2023, 14, 1121063.10.3389/fgene.2023.1121063. - DOI - PMC - PubMed
    1. Liu L.; Yan Q.; Chen Z.; Wei X.; Li L.; Tang D.; Tan J.; Xu C.; Yu C.; Lai Y. Overview of research progress and application of experimental models of colorectal cancer. Frontiers in Pharmacology 2023, 14, 1193213.10.3389/fphar.2023.1193213. - DOI - PMC - PubMed