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. 2024 Apr 2:11:1326092.
doi: 10.3389/fnut.2024.1326092. eCollection 2024.

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Xinyu Shi  1 , Yalan Xiong  1 , Hualing Song  1 , Fen Rong  1 , Nan Tang  1 , Leping Zhu  1 , Shenyu Li  1 , Jianying Wang  1 , Lei Zhang  1 , Shengfu You  2 , Guang Ji  1   2   3 , Baocheng Liu  1   3 , Na Wu  1   3
Affiliations

Progress and hotspot of diet or exercise therapy in the treatment of non-alcoholic fatty liver disease

Xinyu Shi et al. Front Nutr. .

Abstract

Introduction: The primary treatment for non-alcoholic fatty liver disease (NAFLD) is modifying lifestyle through dietary or exercise interventions. In recent decades, it has received increasing attention. However, the lack of bibliometric analysis has posed a challenge for researchers seeking to understand the overall trends in this field.

Methods: As of February 3rd, 2024, 876 articles on treating NAFLD through diet or exercise therapy from 2013 to 2023 had been retrieved. Two software tools, VOSviewer and CiteSpace, were utilized to analyze the growth of publications, countries, institutions, authors, journals, citations, and keywords. Additionally, the keywords with strong citation burstiness were identified to determine the changes and future trends of research hotspots in this field.

Results: China had the highest number of articles, followed by the United States and South Korea. Yonsei University and Nutrients were the institutions and journals with the most significant contributions. Professor Younossi Zobair M, from the United States, is the most prolific author in this field. Through analyzing the keywords, three research hotspots were identified: research on the pathogenesis of NAFLD, research on the treatment modalities of NAFLD, and research on the risk factors and diagnosis methods of NAFLD. In recent years, the research emphasis in this field has changed, suggesting that future research will focus on two frontier keywords: "oxidative stress" and "aerobic capacity."

Conclusion: In the past eleven years, the attention in this field was still rising, and the authors, journals, countries and so on had formed a considerable cooperative relationship. There were also many highly influential and productive researchers in this field. It is speculated that new research will continue around "aerobic exercise" and "oxidative stress" in the future.

Keywords: CiteSpace; VOSviewer; diet therapy; exercise therapy; non-alcoholic fatty liver disease.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The annual distribution of publications. Annual distribution of diet or exercise therapy publications for non-alcoholic fatty liver disease from 2013 to 2023.
Figure 2
Figure 2
Analysis of national cooperation based on the VOSviewer visualization map. The node size is positively correlated with the frequency of node content, and the thickness of the connection line is positively correlated with the co-occurrence times of node content at both ends. Different color clustering reflects the cooperative relationship between countries.
Figure 3
Figure 3
Analysis of author cooperation based on the VOSviewer visual map. The node size is positively correlated with the frequency of node content, and the thickness of the connection line is positively correlated with the co-occurrence times of node content at both ends; different color clustering reflects the cooperative relationship between authors.
Figure 4
Figure 4
Analysis of institutional cooperation based on the VOSviewer visualization map. The node size is positively correlated with the frequency of node content, and the thickness of the connection line is positively correlated with the co-occurrence times of node content at both ends; different color clustering reflects the cooperative relationship between institutions.
Figure 5
Figure 5
Analysis of co-cited literature based on the VOSviewer visualization map In network visualization, the size of nodes depends on the frequency of co-citation. The greater the citation frequency, the greater the contribution of the articles at both ends of the node to the future development of this field.
Figure 6
Figure 6
Analysis of keywords based on the VOSviewer visual map. The node size is positively correlated with the frequency of node content, and the thickness of the connection line is positively correlated with the co-occurrence times of node content at both ends; different color clustering reflects the cooperative relationship between keywords.
Figure 7
Figure 7
A timeline view of keywords. Each period corresponds to a longitudinal time axis, and the keywords on the time axis represent the first appearance of the keywords in this period; The node size represents the total frequency of this keyword for several years. The annual ring of node content, the color of each layer represents the year when the keyword reappears, and the thickness is the frequency of this year; Connecting means co-occurrence.
Figure 8
Figure 8
Top 17 keywords with the strongest citation bursts. The table shows the outbreak keywords in the field of diet or exercise therapy for non-alcoholic fatty liver disease in recent 10 years and ranks them according to the years when they appeared.
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Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by a three-year action plan for Shanghai (project number: ZY (2021–2023)-0211), National Natural Science Foundation of China (81973730), Local Colleges Faculty Constitution of Shanghai MSTC 2022 (22010504300), Shanghai Collaborative Innovation Center for Chronic Disease Prevention and Health Services (2021 Science and Technology 02–37); China Postdoctoral Science Foundation, No.72 General Fund, 2022 (2022 M722164); Shanghai 2023 “Science and Technology Innovation Action Plan” Qi Ming Xing Cultivation (Yang Fan Project, 23YF1447700); Shanghai Health Commission for Traditional Chinese Medicine Research (2022QN014); Shanghai University of Traditional Chinese Medicine in 2021 (2021LK008).