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Review
. 2024 Mar 21;30(11):1524-1532.
doi: 10.3748/wjg.v30.i11.1524.

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Yi-Fan Chang  1 , Jia-Jing Li  2 , Tao Liu  1 , Chong-Qing Wei  1 , Li-Wei Ma  3 , Vladimir N Nikolenko  4 , Wei-Long Chang  5
Affiliations
Review

Morphological and biochemical characteristics associated with autophagy in gastrointestinal diseases

Yi-Fan Chang et al. World J Gastroenterol. .

Abstract

Autophagy is a cellular catabolic process characterized by the formation of double-membrane autophagosomes. Transmission electron microscopy is the most rigorous method to clearly visualize autophagic engulfment and degradation. A large number of studies have shown that autophagy is closely related to the digestion, secretion, and regeneration of gastrointestinal (GI) cells. However, the role of autophagy in GI diseases remains controversial. This article focuses on the morphological and biochemical characteristics of autophagy in GI diseases, in order to provide new ideas for their diagnosis and treatment.

Keywords: Autophagy; Biochemical characteristics; Gastrointestinal diseases; Morphological study; Subcellular structure; Transmission electron microscopy.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Overview of autophagy in gastrointestinal diseases. Created with MedPeer (www.medpeer.cn). TEM: Transmission electron microscopy; GI: Gastrointestinal.
See this image and copyright information in PMC

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