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Review
. 2024;19(11):1013-1028.
doi: 10.2217/nnm-2023-0326. Epub 2024 Apr 12.

Oxidative stress-induced neurotoxicity of quantum dots and influencing factors

Qing Fang  1 , Meng Tang  1
Affiliations
Review

Oxidative stress-induced neurotoxicity of quantum dots and influencing factors

Qing Fang et al. Nanomedicine (Lond). 2024.

Abstract

Quantum dots (QDs) have significant potential for treating and diagnosing CNS diseases. Meanwhile, the neurotoxicity of QDs has garnered attention. In this review, we focus on elucidating the mechanisms and consequences of CNS oxidative stress induced by QDs. First, we discussed the pathway of QDs transit into the brain. We then elucidate the relationship between QDs and oxidative stress from in vivo and in vitro studies. Furthermore, the main reasons and adverse outcomes of QDs leading to oxidative stress are discussed. In addition, the primary factors that may affect the neurotoxicity of QDs are analyzed. Finally, we propose potential strategies for mitigating QDs neurotoxicity and outline future perspectives for their development.

Keywords: blood–brain barrier; mechanism; neurotoxicity; oxidative stress; quantum dots; reactive oxygen species.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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