Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 27:15:1362420.
doi: 10.3389/fgene.2024.1362420. eCollection 2024.

The prognostic significance of LncRNA BLACAT1 overexpression in various tumors: a meta-analysis

Xuefen Yan  1 , Nana Zhang  1 , Gang Wang  1 , Jiaheng Wang  1
Affiliations

The prognostic significance of LncRNA BLACAT1 overexpression in various tumors: a meta-analysis

Xuefen Yan et al. Front Genet. .

Abstract

Objective: Recent studies have revealed increasing evidence that the long non-coding RNA bladder cancer associated transcript 1 (LncRNA BLACAT1) plays an essential role in the emergence of different malignancies. This meta-analysis aimed to evaluate the prognostic significance of LncRNA BLACAT1 in various cancers.

Methods: Six electronic databases (PubMed, Embase, Medline, Web of Science, China National Knowledge Infrastructure (CNKI), and the Chinese WanFang database) were comprehensively searched for relevant studies. The analysis of overall survival (OS) and clinicopathological characteristics was conducted.

Results: Nineteen studies with 1,559 patients were eventually eligible to be included in this meta-analysis. High expression level of LncRNA BLACAT1 was identified to be linked with shorter OS (HR: 2.02, 95% CI: 1.66-2.46, p < 0.001) and PFS (HR: 2.424, 95% CI: 1.827-3.020, p < 0.001) in cancer patients as opposed to low expression levels. Subgroup analysis showed that analysis model (multivariate or univariate), cut-off value (mean or median), sample size (more or fewer than 100), and cancer type had little effect on OS in multiple tumors. Moreover, high LncRNA BLACAT1 expression was associated with positive lymph node metastasis (HR: 2.29, 95% CI: 1.66-3.16, p < 0.00001), advanced clinical stage (HR: 2.29, 95% CI: 1.65-3.19, p < 0.00001) and worse differentiation status (HR: 0.58, 95% CI: 0.37-0.92, p = 0.02), compared to low LncRNA BLACAT1 expression.

Conclusion: The findings highlight that high LncRNA BLACAT1 expression might be detrimental and induce a worse prognosis for cancer patients.

Keywords: cancer; long non-coding RNA BLACAT1; meta-analysis; prognosis; survival.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of the study selection process.
FIGURE 2
FIGURE 2
Forest plot shows the association between the LncRNA BLACAT1 expression and overall survival (OS). The rhombus represents the pooled effect, the center of the rhombus represents the pooled effect size, and the width of the rhombus represents the confidence interval. The vertical line represents HR = 1, and any confidence interval crossing this vertical line represents non-statistically significant.
FIGURE 3
FIGURE 3
Forest plot shows the association between the LncRNA BLACAT1 expression and progression-free survival (PFS). The rhombus represents the pooled effect, the center of the rhombus represents the pooled effect size, and the width of the rhombus represents the confidence interval. The vertical line represents HR = 1, and any confidence interval crossing this vertical line represents non-statistically significant.
FIGURE 4
FIGURE 4
Forest plot shows the association between the LncRNA BLACAT1 expression and clinicopathological characteristics of solid tumors: (A) age; (B) gender; (C) smoking; (D) lymph node metastasis; (E) distant metastasis; (F) clinical stage; (G) tumor size; (H) differentiation status. The rhombus represents the pooled effect, the center of the rhombus represents the pooled effect size, and the width of the rhombus represents the confidence interval. The vertical line represents HR = 1, and any confidence interval crossing this vertical line represents non-statistically significant.
FIGURE 5
FIGURE 5
Publication bias analysis of overall survival (OS) data: (A) Begg’s funnel plot of overall survival (OS) in the published studies. (B) Egger’s publication bias plot of OS in the published studies. The X-axis represents the standard error, which is used to measure accuracy. The higher the standard error, the less accurate the test. HR is plotted on the Y-axis. The black dots indicate the impact of LncRNA BLACAT1 on the outcome.
FIGURE 6
FIGURE 6
Funnel plots shows the association between the LncRNA BLACAT1 expression and clinicopathological characteristics: (A) age; (B) gender; (C) smoking; (D) lymph node metastasis; (E) distant metastasis; (F) clinical stage; (G) tumor size; (H) differentiation status. The Y-axis represents the standard error, which is used to measure accuracy. The higher the standard error, the less accurate the test. HR is plotted on the X-axis. The black dots indicate the impact of LncRNA BLACAT1 on the outcome.
FIGURE 7
FIGURE 7
Sensitivity analysis of the pooled HRs of LncRNA BLACAT1 expression and overall survival (OS).
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Aalijahan H., Ghorbian S. (2019). Long non-coding RNAs and cervical cancer. Exp. Mol. Pathol. 106, 7–16. 10.1016/j.yexmp.2018.11.010 - DOI - PubMed
    1. Chen L. L. (2016). Linking long noncoding RNA localization and function. Trends Biochem. Sci. 41 (9), 761–772. 10.1016/j.tibs.2016.07.003 - DOI - PubMed
    1. Chen R., Zhou S., Chen J., Lin S., Ye F., Jiang P. (2020). LncRNA BLACAT1/miR-519d-3p/CREB1 Axis mediates proliferation, apoptosis, migration, invasion, and drug-resistance in colorectal cancer progression. Cancer Manag. Res. 12, 13137–13148. 10.2147/CMAR.S274447 - DOI - PMC - PubMed
    1. Chen W., Hang Y., Xu W., Wu J., Chen L., Chen J., et al. (2018). BLACAT1 predicts poor prognosis and serves as oncogenic lncRNA in small-cell lung cancer. J. Cell Biochem. 120, 2540–2546. 10.1002/jcb.27548 - DOI - PubMed
    1. Cheng H., Tian J., Wang C., Ren L., Wang N. (2020). LncRNA BLACAT1 is upregulated in cervical squamous cell carcinoma (CSCC) and predicts poor survival. Reprod. Sci. 27 (2), 585–591. 10.1007/s43032-019-00058-9 - DOI - PubMed

Publication types

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.

LinkOut - more resources