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. 2024 Apr 8;25(4):77.
doi: 10.1208/s12249-024-02772-3.

Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment

Mengjuan Sun  1 , Jialin Niu  2 , Yin Zhang  2 , Mengrong Wang  1 , Yan Shen  1 , Xiaolan Chen  3 , Yujuan Mao  4 , Qian Li  5
Affiliations

Keratin Formed Bioadhesive Ophthalmic Gel for the Bacterial Conjunctivitis Treatment

Mengjuan Sun et al. AAPS PharmSciTech. .

Abstract

Keratin has the potential to function as the gel matrix in an ophthalmic formulation for the encapsulation of the macrolide antibiotic azithromycin. The quality of this formulation was thoroughly evaluated through various analyses, such as in vitro release assessment, rheological examination, intraocular retention studies in rabbits, assessment of bacteriostatic efficacy, and safety evaluations. It is worth mentioning that the gel demonstrated shear thinning properties and exhibited characteristics of an elastic solid, thereby confirming its structural stability. The gel demonstrated a notable affinity for mucosal surfaces in comparison to traditional azithromycin aqueous solutions. In vitro release testing revealed that drug release transpired via diffusion mechanisms, following a first-order kinetic release pattern. Additionally, the formulated gel exhibited remarkable antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa in bacteriostatic evaluations. Lastly, safety assessments confirmed that the gel eye drops induced minimal irritation and displayed no apparent cytotoxicity, indicating their good safety and biocompatibility for ocular application. Thus, these findings indicated that the prepared azithromycin gel eye drops complied with the requisite standards for ophthalmic preparations.

Keywords: bioadhesive; irritation; keratin; ophthalmic gel; retention.

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References

    1. Liu YC, Lin MT, Ng AHC, Wong TT, Mehta JS. Nanotechnology for the treatment of allergic conjunctival diseases. Pharmaceuticals (Basel). 2020;13(11). https://doi.org/10.3390/ph13110351 .
    1. Liu YC, Ng AHC, Ng XW, Yan P, Venkatraman SS, Mehta JS, et al. Evaluation of a sustained-release prednisolone acetate biodegradable subconjunctival implant in a non-human primate model. Translation Vision Sci Technol. 2017;6(5):9. https://doi.org/10.1167/tvst.6.5.9 . - DOI
    1. Wu KY, Ashkar S, Jain S, Marchand M, Tran SD. Breaking barriers in eye treatment: polymeric nano-based drug-delivery system for anterior segment diseases and glaucoma. Polymers. 2023;15(6). https://doi.org/10.3390/polym15061373 .
    1. Tang X, Liu J, Yan R, Peng Q. Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: a review. Int J Biol Macromol. 2023;242(Pt 3):124902. https://doi.org/10.1016/j.ijbiomac.2023.124902 . - DOI - PubMed
    1. Mofidfar M, Abdi B, Ahadian S, Mostafavi E, Desai TA, Abbasi F, et al. Drug delivery to the anterior segment of the eye: a review of current and future treatment strategies. Int J Pharm. 2021;607:120924. https://doi.org/10.1016/j.ijpharm.2021.120924 . - DOI - PubMed - PMC

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