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Review
. 2024 Mar 15;13(6):895.
doi: 10.3390/foods13060895.

Understanding Ligilactobacillus salivarius from Probiotic Properties to Omics Technology: A Review

Yong Yang  1 , Xin Song  1 , Guangqiang Wang  1 , Yongjun Xia  1 , Zhiqiang Xiong  1 , Lianzhong Ai  1
Affiliations
Review

Understanding Ligilactobacillus salivarius from Probiotic Properties to Omics Technology: A Review

Yong Yang et al. Foods. .

Abstract

Ligilactobacillus salivarius (basonym: Lactobacillus salivarius, L. salivarius) is a type of lactic acid bacteria (LAB) commonly found in the oropharyngeal-gastrointestinal tract (OGT). It has gained significant attention due to its probiotic and functional properties as well as its various health-promoting roles. L. salivarius strains exhibit strong resistance and adhesion in the OGT along with outstanding antioxidant and antimicrobial properties. Additionally, numerous L. salivarius strains have the ability to produce bacteriocins with antagonistic activity. These probiotic characteristics of L. salivarius indicate its remarkable potential in promoting favorable effects on human health. It has also been observed that L. salivarius has a positive effect on the composition of intestinal microbiota, thereby improving the metabolic profiling of intestinal microbiota, promoting a healthy and balanced internal environment. In recent years, multi-omics technologies such as genomics, transcriptomics, proteomics and metabolomics have been employed to gain a deeper understanding of the roles and mechanisms of L. salivarius associated with its functional properties. This review aims to provide an overview of the probiotic characteristics of L. salivarius, containing its specific interactions with the host microflora, as well as insights from omics studies.

Keywords: Ligilactobacillus salivarius; functional properties; gut microbiota; omics technologies; probiotic.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
LAB cell wall structure. LTA represents lipoteichoic acids, WTA represents wall teichoic acids, EPS represents exopolysaccharides, WAP represents wall-associated proteins, SLP represents surface layer proteins, SP represents secreted proteins, MP represents membrane proteins, LP represents lipoproteins and MAP represents membrane-associated proteins.
Figure 2
Figure 2
Active metabolites of probiotics, their functions and applications.
Figure 3
Figure 3
Effects on the gut microbiota following administration of lactobacillus.
Figure 4
Figure 4
Understanding probiotic functional properties using an omics approach.
See this image and copyright information in PMC

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References

    1. Rogosa M., Sharpe M.E. An Approach to the Classification of the Lactobacilli. J. Appl. Bacteriol. 1960;22:329–340.
    1. Rogosa M., Wiseman R.F., Mitchell Joyce A., Disraely M.N., Beaman A.J. Species Differentiation of Oral Lactobacilli from Man Including Descriptions of Lactobacillus salivarius Nov Spec and Lactobacillus cellobiosus Nov Spec. J. Bacteriol. 1953;65:681–699. doi: 10.1128/jb.65.6.681-699.1953. - DOI - PMC - PubMed
    1. Neville B.A., O’Toole P.W. Probiotic Properties Of Lactobacillus salivarius and Closely Related Lactobacillus Species. Future Microbiol. 2010;5:759–774. - PubMed
    1. Zheng J., Wittouck S., Salvetti E., Franz C.M.A.P., Harris H.M.B., Mattarelli P., O’Toole P.W., Pot B., Vandamme P., Walter J. A Taxonomic Note on the Genus Lactobacillus: Description of 23 Novel Genera, Emended Description of the Genus Lactobacillus beijerinck 1901, and Union of Lactobacillaceae and Leuconostocaceae. Int. J. Syst. Evol. Microbiol. 2020;70:2782–2858. doi: 10.1099/ijsem.0.004107. - DOI - PubMed
    1. Dec M., Stępień-Pyśniak D., Puchalski A., Hauschild T., Pietras-Ożga D., Ignaciuk S., Urban-Chmiel R. Biodiversity of Ligilactobacillus salivarius Strains from Poultry and Domestic Pigeons. Animals. 2021;11:972. doi: 10.3390/ani11040972. - DOI - PMC - PubMed

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