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Review
. 2024 Mar 19;25(1):134.
doi: 10.1186/s12931-024-02763-9.

The role of sialidase Neu1 in respiratory diseases

Shiran Mei #  1 , Dingding Li #  1 , Aoyi Wang #  1 , Guoxue Zhu  1 , Bingwen Zhou  1 , Nian Li  1 , Yi Qin  1 , Yanliang Zhang  2   3 , Shujun Jiang  4   5
Affiliations
Review

The role of sialidase Neu1 in respiratory diseases

Shiran Mei et al. Respir Res. .

Abstract

Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.

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Conflict of interest statement

The authors have no competing interest to declare with regards to the manuscript.

Figures

Fig. 1
Fig. 1
Schematic view of the role of the Neu1 in respiratory disease
Fig. 2
Fig. 2
Expression of NEU1 in lung carcinoma in TCGA database. A Expression of NEU1 in lung cancer (LC), lung adenocarcinoma (LA) or lung squamous cell carcinoma(LSCC); B expression of NEU2 in LC/LA/LSCC; C expression of NEU3 in LC/LA/LSCC; D expression of NEU4 in LC/LA/LSCC; (lung cancer (n = 1093) lung adenocarcinoma (n = 556), lung squamous cell carcinoma (n = 538) ***p < 0.001, **p < 0.01, *p < 0.05, − p < 1)
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