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Review
. 2024 Apr 20:131:111854.
doi: 10.1016/j.intimp.2024.111854. Epub 2024 Mar 12.

The role of ANXA1 in the tumor microenvironment

Lanxin Li  1 , Baiqi Wang  2 , Shuang Zhao  1 , Qinglin Xiong  1 , Ailan Cheng  3
Affiliations
Review

The role of ANXA1 in the tumor microenvironment

Lanxin Li et al. Int Immunopharmacol. .

Abstract

Annexin A1 (ANXA1) is widely expressed in a variety of body tissues and cells and is also involved in tumor development through multiple pathways. The invasion, metastasis, and immune escape of tumor cells depend on the interaction between tumor cells and their surrounding environment. Research shows that ANXA1 can act on a variety of cells in the tumor microenvironment (TME), and subsequently affect the proliferation, invasion and metastasis of tumors. This article describes the role of ANXA1 in the various components of the tumor microenvironment and its mechanism of action, as well as the existing clinical treatment measures related to ANXA1. These findings provide insight for the further design of strategies targeting ANXA1 for the diagnosis and treatment of malignant tumors.

Keywords: Angiogenesis; AnnexinA1; Immune; Inflammation; Tumor microenvironment.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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