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. 2024 Mar 13;19(3):e0299484.
doi: 10.1371/journal.pone.0299484. eCollection 2024.

The preventative effects of statin on lung cancer development in patients with idiopathic pulmonary fibrosis using the National Health Insurance Service Database in Korea

Yoo Jung Lee  1 , Nayoon Kang  2 , Junghyun Nam  3 , Eung Gu Lee  4 , Jiwon Ryoo  4 , Soon Seog Kwon  4 , Yong Hyun Kim  4 , Hye Seon Kang  4
Affiliations

The preventative effects of statin on lung cancer development in patients with idiopathic pulmonary fibrosis using the National Health Insurance Service Database in Korea

Yoo Jung Lee et al. PLoS One. .

Abstract

Little is known about the effect of statin use in lung cancer development in idiopathic pulmonary fibrosis (IPF). We analyzed the database of the National Health Insurance Service to further investigate the clinical impacts of statin on lung cancer development and overall survival (OS) in IPF patients. The analysis included 9,182 individuals diagnosed with IPF, of which 3,372 (36.7%) were statin users. Compared to statin non-users, the time from diagnosis of IPF to lung cancer development and OS were longer in statin users in IPF patients. In Cox proportional hazard regression models, higher statin compliance, statin use, and being female had an inverse association with lung cancer risk, while older age at diagnosis of IPF and smoking history were associated with higher risk of lung cancer in IPF patients. For OS, statin use, female sex, higher physical activity frequency, and diabetes were associated with longer survival. In contrast, older age at diagnosis of IPF and smoking history were associated with shorter OS in IPF patients. These data from a large population indicate that statin had an independent protective association with lung cancer development and mortality in IPF patients.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1
Kaplan-Meier plot displaying cumulative incidence of lung cancer development (A) and overall survival (B) in IPF patients with and without statin use. IPF = idiopathic pulmonary fibrosis, K-M = Kaplan-Meier.
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Grants and funding

This work was supported by the Institute of Clinical Medicine Research of Bucheon St. Mary’s Hospital, Research Fund, 2020 (BCMC20BD07). here was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.