The regulation of the pedunculopontine tegmental nucleus in sleep-wake states

doi:10.1007/s41105-023-00489-7

Review

. 2023 Sep 26;22(1):5-11.

doi: 10.1007/s41105-023-00489-7. eCollection 2024 Jan.

The regulation of the pedunculopontine tegmental nucleus in sleep-wake states

Yiting Luo^{1

2}, Ying Li^{1

2}, Jie Yuan^{1

2

3}

Affiliations

¹ Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, No.149 Dalian Road, Huichuan District, Zunyi, 563000 Guizhou China.
² Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou China.
³ Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyin, China.

PMID: 38469582
PMCID: PMC10900045
DOI: 10.1007/s41105-023-00489-7

Review

The regulation of the pedunculopontine tegmental nucleus in sleep-wake states

Yiting Luo et al. Sleep Biol Rhythms. 2023.

. 2023 Sep 26;22(1):5-11.

doi: 10.1007/s41105-023-00489-7. eCollection 2024 Jan.

Authors

Yiting Luo^{1

2}, Ying Li^{1

2}, Jie Yuan^{1

2

3}

Affiliations

¹ Department of Anesthesiology, The Affiliated Hospital of Zunyi Medical University, No.149 Dalian Road, Huichuan District, Zunyi, 563000 Guizhou China.
² Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000 Guizhou China.
³ Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical University, Zunyin, China.

PMID: 38469582
PMCID: PMC10900045
DOI: 10.1007/s41105-023-00489-7

Abstract

The pedunculopontine tegmental nucleus (PPTg) plays a vital role in sleep/wake states. There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic, and gamma-aminobutyric acidergic (GABAergic) neurons. However, the precise roles of cholinergic, glutamatergic and GABAergic PPTg cell groups in regulating sleep-wake are unknown. Recent work suggests that the cholinergic, glutamatergic, and GABAergic neurons of the PPTg may activate the main arousal-promoting nucleus, thus exerting their wakefulness effects. We review the related projection pathways and functions of various neurons of the PPTg, especially the mechanisms of the PPTg in sleep-wake, thus providing new perspectives for research of sleep-wake mechanisms.

Keywords: Cholinergic neurons; GABAergic neurons; Glutamatergic neurons; PPTg; Sleep–wake.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

References

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[1] Borbely A. The two-process model of sleep regulation: beginnings and outlook. J Sleep Res. 2022;31(4):e13598. doi: 10.1111/jsr.13598. - DOI - PMC - PubMed

[2] Borbely A. The two-process model of sleep regulation: beginnings and outlook. J Sleep Res. 2022;31(4):e13598. doi: 10.1111/jsr.13598. - DOI - PMC - PubMed

[3] Saper CB, et al. Sleep state switching. Neuron. 2010;68(6):1023–1042. doi: 10.1016/j.neuron.2010.11.032. - DOI - PMC - PubMed

[4] Saper CB, et al. Sleep state switching. Neuron. 2010;68(6):1023–1042. doi: 10.1016/j.neuron.2010.11.032. - DOI - PMC - PubMed

[5] Scammell TE, Arrigoni E, Lipton JO. Neural circuitry of wakefulness and sleep. Neuron. 2017;93(4):747–765. doi: 10.1016/j.neuron.2017.01.014. - DOI - PMC - PubMed

[6] Scammell TE, Arrigoni E, Lipton JO. Neural circuitry of wakefulness and sleep. Neuron. 2017;93(4):747–765. doi: 10.1016/j.neuron.2017.01.014. - DOI - PMC - PubMed

[7] Wang YQ, et al. Neural circuitry underlying REM sleep: a review of the literature and current concepts. Prog Neurobiol. 2021;204:102106. doi: 10.1016/j.pneurobio.2021.102106. - DOI - PubMed

[8] Wang YQ, et al. Neural circuitry underlying REM sleep: a review of the literature and current concepts. Prog Neurobiol. 2021;204:102106. doi: 10.1016/j.pneurobio.2021.102106. - DOI - PubMed

[9] Lindsley DB, Bowden JW, Magoun HW. Effect upon the EEG of acute injury to the brain stem activating system. Electroencephalogr Clin Neurophysiol. 1949;1(4):475–486. doi: 10.1016/0013-4694(49)90221-7. - DOI - PubMed

[10] Lindsley DB, Bowden JW, Magoun HW. Effect upon the EEG of acute injury to the brain stem activating system. Electroencephalogr Clin Neurophysiol. 1949;1(4):475–486. doi: 10.1016/0013-4694(49)90221-7. - DOI - PubMed

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The regulation of the pedunculopontine tegmental nucleus in sleep-wake states

Affiliations

The regulation of the pedunculopontine tegmental nucleus in sleep-wake states

Authors

Affiliations

Abstract

Conflict of interest statement

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