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Review
. 2024 Feb 22:12:1355848.
doi: 10.3389/fchem.2024.1355848. eCollection 2024.

The function of chemical folic acid in calibration methods and neurodevelopmental disorders

Ziqi Zhou  1 , Meng Wang  2 , Qiongli Fan  3 , Yan Zhao  1 , Nianrong Wang  1
Affiliations
Review

The function of chemical folic acid in calibration methods and neurodevelopmental disorders

Ziqi Zhou et al. Front Chem. .

Abstract

Functional molecules have been attracting increasing attention in environmental and physiological studies. In particular, folic acid (FA) could be considered a key factor in estimating, adjusting, and making decisions in the treatment of neurodevelopmental disorders. It promotes the general significance and conceptual for considering FA molecular scientific research detections, which implies related advancement in both of biological structure and detection methods. Among these applications, the FA molecule acts as a coenzyme that incorporates carbon atoms and synthesizes purines and pyrimidines. Therefore, the calibration method has real applications and can be used as a sensing platform and for detection approaches, which conveys the internal relationship between the FA molecule and physiological characterization. This mini review briefly discusses multiple FA application fields and detection pathways and could supplement their utilization in anticipation of the onset of disease.

Keywords: biological structure; detections; folic acid; functions; neurodevelopmental disorder.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
(A) Visual detection of folic acid (FA) based on silica-coated CdTeS quantum dots in serum samples (Qian et al., 2018). (B) The full structure of FA derivative in sensing platforms undergoing an electron transferring phenomenon (Li and Yan, 2019). (C) Selective detection of FA using a water-stable fluorescent CsPbBr3/Cs4PbBr6 perovskite nanocrystal probe (She et al., 2023). (D) Magnetic microrobots with FA targeting for drug delivery and induced molecular recognition. (E) FA metabolism with a re-emerging therapeutic target in hematological cancers and physiological characterization. Reproduced from Yang et al. (2021) with the permission of the Materials Research Bulletin. Reproduced from Zhou et al. (2022) with the permission of Analytical and Bioanalytical Chemistry. Reproduced from She et al. (2023) with the permission of Chemosensor. Reproduced from Ye et al. (2023) with the permission of Cyborg and Bionic Systems. Reproduced from Zarou et al. (2021) with the permission of Leukemia.
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References

    1. Abbasi M., Sohail M., Minhas M. U., Mahmood A., Shah S. A., Munir A., et al. (2023). Folic acid-decorated alginate nanoparticles loaded hydrogel for the oral delivery of diferourylmethane in colorectal cancer. Int. J. Biol. Macromol. 233, 123585. 10.1016/j.ijbiomac.2023.123585 - DOI - PubMed
    1. Akbar S., Anwar A., Kanwal Q. (2016). Electrochemical determination of folic acid: a short review. Anal. Biochem. 510, 98–105. 10.1016/j.ab.2016.07.002 - DOI - PubMed
    1. Amirishoar M., Noori S., Mohammadnejad J., Bazl M. R., Narmani A. (2023). Design and fabrication of folic acid-conjugated and gold-loaded poly (lactic-co-glycolic acid) biopolymers for suppression of breast cancer cell survival combining photothermal and photodynamic therapy. J. Drug Deliv. Sci. Tec. 83, 104266. 10.1016/j.jddst.2023.104266 - DOI
    1. Berry R. J. (1999). Prevention of neural-tube defects with folic acid in China. China-U.S. collaborative project for neural tube defect prevention. New Engl. J. Med. 341, 1864. 10.1056/NEJM199912093412424 - DOI - PubMed
    1. Bjork M., Riedel B., Spigset O., Veiby G., Kolstad E., Daltveit A. K., et al. (2017). Association of folic acid supplementation during pregnancy with the risk of autistic traits in children exposed to antiepileptic drugs in utero . Jama Neurol. 75, 160. 10.1001/jamaneurol.2017.3897 - DOI - PMC - PubMed

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Chongqing Municipal Special Project for Technological Innovation and Application Development (CSTB2022TIAD-LDX0002).

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