Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

doi:10.4252/wjsc.v16.i2.89

Review

. 2024 Feb 26;16(2):89-101.

doi: 10.4252/wjsc.v16.i2.89.

Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

Pier Luigi Surico^{1

2}, Anna Scarabosio³, Giovanni Miotti³, Martina Grando⁴, Carlo Salati⁵, Pier Camillo Parodi³, Leopoldo Spadea⁶, Marco Zeppieri⁷

Affiliations

¹ Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.
² Department of Ophthalmology, Campus Bio-Medico University, Rome 00128, Italy.
³ Department of Plastic Surgery, University Hospital of Udine, Udine 33100, Italy.
⁴ Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, San Vito al Tagliamento 33078, Italy.
⁵ Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
⁶ Eye Clinic, Policlinico Umberto I, "Sapienza" University of Rome, Rome 00142, Italy.
⁷ Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy. markzeppieri@hotmail.com.

PMID: 38455097
PMCID: PMC10915950
DOI: 10.4252/wjsc.v16.i2.89

Review

Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

Pier Luigi Surico et al. World J Stem Cells. 2024.

. 2024 Feb 26;16(2):89-101.

doi: 10.4252/wjsc.v16.i2.89.

Authors

Pier Luigi Surico^{1

2}, Anna Scarabosio³, Giovanni Miotti³, Martina Grando⁴, Carlo Salati⁵, Pier Camillo Parodi³, Leopoldo Spadea⁶, Marco Zeppieri⁷

Affiliations

¹ Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA 02114, United States.
² Department of Ophthalmology, Campus Bio-Medico University, Rome 00128, Italy.
³ Department of Plastic Surgery, University Hospital of Udine, Udine 33100, Italy.
⁴ Department of Internal Medicine, Azienda Sanitaria Friuli Occidentale, San Vito al Tagliamento 33078, Italy.
⁵ Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
⁶ Eye Clinic, Policlinico Umberto I, "Sapienza" University of Rome, Rome 00142, Italy.
⁷ Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy. markzeppieri@hotmail.com.

PMID: 38455097
PMCID: PMC10915950
DOI: 10.4252/wjsc.v16.i2.89

Abstract

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enhancement, demands advanced solutions for tissue restoration, functional and aesthetic refinement, and aging. Investigating immunomodulatory, regenerative, and healing capacities of MSCs, this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside, addressing common unmet needs in the field of reconstructive and regenerative surgery.

Keywords: Adipose stem cell; Ocular therapy; Oculoplastics; Regenerative; Stem cells.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Cited by

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Whole-eye transplantation: Current challenges and future perspectives.
Scarabosio A, Surico PL, Tereshenko V, Singh RB, Salati C, Spadea L, Caputo G, Parodi PC, Gagliano C, Winograd JM, Zeppieri M. Scarabosio A, et al. World J Transplant. 2024 Jun 18;14(2):95009. doi: 10.5500/wjt.v14.i2.95009. World J Transplant. 2024. PMID: 38947970 Free PMC article. Review.

References

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[1] Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–317. - PubMed

[2] Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop Dj, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315–317. - PubMed

[3] Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8:726–736. - PubMed

[4] Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol. 2008;8:726–736. - PubMed

[5] Costela-Ruiz VJ, Melguizo-Rodríguez L, Bellotti C, Illescas-Montes R, Stanco D, Arciola CR, Lucarelli E. Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications. Int J Mol Sci. 2022;23 - PMC - PubMed

[6] Costela-Ruiz VJ, Melguizo-Rodríguez L, Bellotti C, Illescas-Montes R, Stanco D, Arciola CR, Lucarelli E. Different Sources of Mesenchymal Stem Cells for Tissue Regeneration: A Guide to Identifying the Most Favorable One in Orthopedics and Dentistry Applications. Int J Mol Sci. 2022;23 - PMC - PubMed

[7] Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR. Mesenchymal stem cells: Cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019;13:1738–1755. - PubMed

[8] Brown C, McKee C, Bakshi S, Walker K, Hakman E, Halassy S, Svinarich D, Dodds R, Govind CK, Chaudhry GR. Mesenchymal stem cells: Cell therapy and regeneration potential. J Tissue Eng Regen Med. 2019;13:1738–1755. - PubMed

[9] Guillamat-Prats R. The Role of MSC in Wound Healing, Scarring and Regeneration. Cells. 2021;10 - PMC - PubMed

[10] Guillamat-Prats R. The Role of MSC in Wound Healing, Scarring and Regeneration. Cells. 2021;10 - PMC - PubMed

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Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

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Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics

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