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Review
. 2024 Apr;154(4):1069-1079.
doi: 10.1016/j.tjnut.2024.03.002. Epub 2024 Mar 6.

A Perspective Review on Diet Quality, Excess Adiposity, and Chronic Psychosocial Stress and Implications for Early-Onset Colorectal Cancer

Manoela Lima Oliveira  1 , Alana Biggers  2 , Vanessa M Oddo  3 , Betina Yanez  4 , Emily Booms  5 , Lisa Sharp  6 , Keith Naylor  2 , Patricia G Wolf  7 , Lisa Tussing-Humphreys  3
Affiliations
Review

A Perspective Review on Diet Quality, Excess Adiposity, and Chronic Psychosocial Stress and Implications for Early-Onset Colorectal Cancer

Manoela Lima Oliveira et al. J Nutr. 2024 Apr.

Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide. Although the overall incidence of CRC has been decreasing over the past 40 y, early-onset colorectal cancer (EOCRC), which is defined as a CRC diagnosis in patients aged >50 y has increased. In this Perspective, we highlight and summarize the association between diet quality and excess adiposity, and EOCRC. We also explore chronic psychosocial stress (CPS), a less investigated modifiable risk factor, and EOCRC. We were able to show that a poor-quality diet, characterized by a high intake of sugary beverages and a Western diet pattern (high intake of red and processed meats, refined grains, and foods with added sugars) can promote risk factors associated with EOCRC development, such as an imbalance in the composition and function of the gut microbiome, presence of chronic inflammation, and insulin resistance. Excess adiposity, particularly obesity onset in early adulthood, is a likely contributor of EOCRC. Although the research is sparse examining CPS and CRC/EOCRC, we describe likely pathways linking CPS to tumorigenesis. Although additional research is needed to understand what factors are driving the uptick in EOCRC, managing body weight, improving diet quality, and mitigating psychosocial stress, may play an important role in reducing an individual's risk of EOCRC.

Keywords: Western diet; cancer prevention; chronic psychosocial stress; colorectal cancer; diet quality; early-onset colorectal cancer; excess adiposity; lifestyle factors; obesity.

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Figures

FIGURE 1
FIGURE 1
Hypothalamic-pituitary-adrenal axis response in acute compared with chronic stress. Template adapted from: Camilla Maria Fontana, PhD Student, University of Padova. Template created with Biorender (biorender.com).
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