mTORC2: The "Ace in the Hole" for a Broader Control of Epileptic Seizures?

doi:10.1007/s12264-024-01187-1

. 2024 May;40(5):677-679.

doi: 10.1007/s12264-024-01187-1. Epub 2024 Mar 7.

mTORC2: The "Ace in the Hole" for a Broader Control of Epileptic Seizures?

Shuo Zhang¹, Xiongfeng Guo², Wei Huang¹, Cenglin Xu^{3

4}

Affiliations

¹ Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
² The Second Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Xinhua Hospital); Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
³ Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. xucenglin5zz@zju.edu.cn.
⁴ The Second Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Xinhua Hospital); Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. xucenglin5zz@zju.edu.cn.

PMID: 38451388
PMCID: PMC11127853 (available on 2025-05-01)
DOI: 10.1007/s12264-024-01187-1

mTORC2: The "Ace in the Hole" for a Broader Control of Epileptic Seizures?

Shuo Zhang et al. Neurosci Bull. 2024 May.

. 2024 May;40(5):677-679.

doi: 10.1007/s12264-024-01187-1. Epub 2024 Mar 7.

Authors

Shuo Zhang¹, Xiongfeng Guo², Wei Huang¹, Cenglin Xu^{3

4}

Affiliations

¹ Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China.
² The Second Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Xinhua Hospital); Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
³ Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310006, China. xucenglin5zz@zju.edu.cn.
⁴ The Second Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Xinhua Hospital); Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. xucenglin5zz@zju.edu.cn.

PMID: 38451388
PMCID: PMC11127853 (available on 2025-05-01)
DOI: 10.1007/s12264-024-01187-1

No abstract available

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Conflict of interest statement

The authors declare no conflicts of interest.

Cited by

Novel Mechanism, Drug Target and Therapy in Epilepsy.
Xu C, Wang Y, Chen Z. Xu C, et al. Neurosci Bull. 2024 May;40(5):561-563. doi: 10.1007/s12264-024-01215-0. Epub 2024 Apr 24. Neurosci Bull. 2024. PMID: 38658515 No abstract available.

References

1. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet. 2019;393:689–701. doi: 10.1016/S0140-6736(18)32596-0. - DOI - PubMed
1. Xu C, Gong Y, Wang Y, Chen Z. New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments. Pharmacol Ther. 2022;233:108026. doi: 10.1016/j.pharmthera.2021.108026. - DOI - PubMed
1. Gerasimenko A, Baldassari S, Baulac S. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy. Neurobiol Dis. 2023;182:106144. doi: 10.1016/j.nbd.2023.106144. - DOI - PubMed
1. Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ, et al. Targeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun. 2023;14:7364. doi: 10.1038/s41467-023-42922-y. - DOI - PMC - PubMed
1. Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, et al. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol. 2018;83:311–327. doi: 10.1002/ana.25149. - DOI - PMC - PubMed

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[1] Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet. 2019;393:689–701. doi: 10.1016/S0140-6736(18)32596-0. - DOI - PubMed

[2] Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet. 2019;393:689–701. doi: 10.1016/S0140-6736(18)32596-0. - DOI - PubMed

[3] Xu C, Gong Y, Wang Y, Chen Z. New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments. Pharmacol Ther. 2022;233:108026. doi: 10.1016/j.pharmthera.2021.108026. - DOI - PubMed

[4] Xu C, Gong Y, Wang Y, Chen Z. New advances in pharmacoresistant epilepsy towards precise management-from prognosis to treatments. Pharmacol Ther. 2022;233:108026. doi: 10.1016/j.pharmthera.2021.108026. - DOI - PubMed

[5] Gerasimenko A, Baldassari S, Baulac S. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy. Neurobiol Dis. 2023;182:106144. doi: 10.1016/j.nbd.2023.106144. - DOI - PubMed

[6] Gerasimenko A, Baldassari S, Baulac S. mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy. Neurobiol Dis. 2023;182:106144. doi: 10.1016/j.nbd.2023.106144. - DOI - PubMed

[7] Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ, et al. Targeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun. 2023;14:7364. doi: 10.1038/s41467-023-42922-y. - DOI - PMC - PubMed

[8] Okoh J, Mays J, Bacq A, Oses-Prieto JA, Tyanova S, Chen CJ, et al. Targeted suppression of mTORC2 reduces seizures across models of epilepsy. Nat Commun. 2023;14:7364. doi: 10.1038/s41467-023-42922-y. - DOI - PMC - PubMed

[9] Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, et al. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol. 2018;83:311–327. doi: 10.1002/ana.25149. - DOI - PMC - PubMed

[10] Talos DM, Jacobs LM, Gourmaud S, Coto CA, Sun H, Lim KC, et al. Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Ann Neurol. 2018;83:311–327. doi: 10.1002/ana.25149. - DOI - PMC - PubMed

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mTORC2: The "Ace in the Hole" for a Broader Control of Epileptic Seizures?

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mTORC2: The "Ace in the Hole" for a Broader Control of Epileptic Seizures?

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