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Review
. 2024 Mar 4;206(4):136.
doi: 10.1007/s00203-024-03838-3.

The relationship between autophagy and respiratory viruses

Hamidreza Gheitasi  1 , Mohammad Sabbaghian  1 , Manouchehr Fadaee  2 , Nader Mohammadzadeh  1 , Ali Akbar Shekarchi  3 , Vahdat Poortahmasebi  4   5
Affiliations
Review

The relationship between autophagy and respiratory viruses

Hamidreza Gheitasi et al. Arch Microbiol. .

Abstract

Respiratory viruses have caused severe global health problems and posed essential challenges to the medical community. In recent years, the role of autophagy as a critical process in cells in viral respiratory diseases has been noticed. One of the vital catabolic biological processes in the body is autophagy. Autophagy contributes to energy recovery by targeting and selectively directing foreign microorganisms, organelles, and senescent intracellular proteins to the lysosome for degradation and phagocytosis. Activation or suppression of autophagy is often initiated when foreign pathogenic organisms such as viruses infect cells. Because of its antiviral properties, several viruses may escape or resist this process by encoding viral proteins. Viruses can also use autophagy to enhance their replication or prolong the persistence of latent infections. Here, we provide an overview of autophagy and respiratory viruses such as coronavirus, rhinovirus, parainfluenza, influenza, adenovirus, and respiratory syncytial virus, and examine the interactions between them and the role of autophagy in the virus-host interaction process and the resulting virus replication strategy.

Keywords: Autophagy; Virus replication; Viruses.

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References

    1. Abdoli A, Alirezaei M, Mehrbod P, Forouzanfar F (2018) Autophagy: the multi-purpose bridge in viral infections and host cells. Rev Med Virol 28(4):e1973 - PubMed - PMC - DOI
    1. Agrotis A, von Chamier L, Oliver H, Kiso K, Singh T, Ketteler R (2019) Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins. J Biol Chem 294(34):12610–12621 - PubMed - PMC - DOI
    1. Ahmadi M, Roy R (2012) 5′-AMP-activated protein kinase signaling in Caenorhabditis elegans. Exp Suppl 2016(107):375–388
    1. Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF et al (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460(7251):108–112 - PubMed - PMC - DOI
    1. Bagniewska-Zadworna A, Arasimowicz-Jelonek M (2016) The mystery of underground death: cell death in roots during ontogeny and in response to environmental factors. Plant Biol 18(2):171–184 - PubMed - DOI

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