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Review
. 2024 May;239(5):e31229.
doi: 10.1002/jcp.31229. Epub 2024 Mar 1.

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Shahenda Salah Abdelsam  1 , Sarah Khalaf Ghanem  1 , Muhammad Ammar Zahid  1 , Hanan H Abunada  2 , Loulia Bader  1 , Hicham Raïq  3 , Abbas Khan  1 , Aijaz Parray  4 , Laiche Djouhri  5 , Abdelali Agouni  1   6
Affiliations
Review

Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders

Shahenda Salah Abdelsam et al. J Cell Physiol. 2024 May.

Abstract

RNA-binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that plays a crucial role as a posttranscriptional regulator. HuR plays a crucial role in the amplification of inflammatory signals by stabilizing the messenger RNA of diverse inflammatory mediators and key molecular players. The noteworthy correlations between HuR and its target molecules, coupled with the remarkable impacts reported on the pathogenesis and advancement of multiple diseases, position HuR as a promising candidate for therapeutic intervention in diverse inflammatory conditions. This review article examines the significance of HuR as a member of the RBP family, its regulatory mechanisms, and its implications in the pathophysiology of inflammation and cardiometabolic illnesses. Our objective is to illuminate potential directions for future research and drug development by conducting a comprehensive analysis of the existing body of research on HuR.

Keywords: HuR; RNA‐binding proteins (RBPs); abnormal vision Drosophila‐like 1 (ELAVL1); cardiometabolic disease; inflammation.

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