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Review
. 2024;24(8):686-721.
doi: 10.2174/0115680266287101240214071718.

The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine

Kalpesh Mahajan  1 , Sankha Bhattacharya  2
Affiliations
Review

The Advancement and Obstacles in Improving the Stability of Nanocarriers for Precision Drug Delivery in the Field of Nanomedicine

Kalpesh Mahajan et al. Curr Top Med Chem. 2024.

Abstract

Nanocarriers have emerged as a promising class of nanoscale materials in the fields of drug delivery and biomedical applications. Their unique properties, such as high surface area- tovolume ratios and enhanced permeability and retention effects, enable targeted delivery of therapeutic agents to specific tissues or cells. However, the inherent instability of nanocarriers poses significant challenges to their successful application. This review highlights the importance of nanocarrier stability in biomedical applications and its impact on biocompatibility, targeted drug delivery, long shelf life, drug delivery performance, therapeutic efficacy, reduced side effects, prolonged circulation time, and targeted delivery. Enhancing nanocarrier stability requires careful design, engineering, and optimization of physical and chemical parameters. Various strategies and cutting-edge techniques employed to improve nanocarrier stability are explored, with a focus on their applications in drug delivery. By understanding the advances and challenges in nanocarrier stability, this review aims to contribute to the development and implementation of nanocarrier- based therapies in clinical settings, advancing the field of nanomedicine.

Keywords: Drug delivery; Nanocarrier stability; Nanocarriers; Nanomedicine; Nanoscale materials.; Targeted drug delivery.

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References

    1. Patra J.K.; Das G.; Fraceto L.F.; Campos E.V.R.; Rodriguez-Torres M.P.; Acosta-Torres L.S.; Diaz-Torres L.A.; Grillo R.; Swamy M.K.; Sharma S.; Habtemariam S.; Shin H.S.; Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology 2018,16(1),71 - DOI - PubMed
    1. Joseph T.; Kar Mahapatra D.; Esmaeili A.; Piszczyk Ł.; Hasanin M.; Kattali M.; Haponiuk J.; Thomas S.; Nanoparticles: Taking a Unique Position in Medicine. Nanomaterials 2023,13(3),574 - DOI - PubMed
    1. Dong X.; Current strategies for brain drug delivery. Theranostics 2018,8(6),1481-1493 - DOI - PubMed
    1. Blanco E.; Shen H.; Ferrari M.; Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 2015,33(9),941-951 - DOI - PubMed
    1. Mitchell M.J.; Billingsley M.M.; Haley R.M.; Wechsler M.E.; Peppas N.A.; Langer R.; Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov 2021,20(2),101-124 - DOI - PubMed

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